Vitamin D level among patients with unexplained musculoskeletal symptoms

Authors

  • Md. Abdur Razzaque Department of Rheumatology, Chittagong Medical College, Chattogram, Bangladesh, Email: rhrazzaq@gmail.com https://orcid.org/0000-0002-2395-542X
  • Iftekhar Hussain Bandhan Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Email: ibandhan@gmail.com https://orcid.org/0000-0002-3800-6155
  • Rijwan Bhuiyan Department of Epidemiology, Ekhlaspur Centre of Health, Chandpur, Bangladesh, Email: physiorijwan@gmail.com https://orcid.org/0000-0003-0005-8889
  • Mohammad Ziaul Haider Department of Rheumatology, Rajshahi Medical College, Rajshahi, Bangladesh, Email: drziaulhaider@hotmail.com
  • Mirza Nurul Karim Department of Rheumatology, Chittagong Medical College, Chattogram, Bangladesh, Email: rhrazzaq@gmail.com
  • Minhaj Rahim Choudhury Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Email: drminhaj11@gmail.com

DOI:

https://doi.org/10.3329/bsmmuj.v16i4.70186

Keywords:

Vitamin D, hypovitaminosis D, unexplained MSK symptoms , musculoskeletal symptoms

Abstract

Background: Unexplained musculoskeletal (MSK) symptoms sometimes pose diagnostic and management challenges and can lead to prolonged suffering and disability. Hypovitaminosis D could be a reason for such symptoms. This study aimed to determine the vitamin D level among patients with unexplained MSK symptoms.

Methods: A cross-sectional study was conducted in a private clinic of Chattogram city, Bangladesh. A total of 110 unexplained MSK patients were enrolled conveniently. MSK symptoms were assessed by rheumatologist and serum vitamin D levels were measured according to the standard laboratory procedure. Descriptive and logistic regression analyses were done. Principal component analysis was performed for the reduction of MSK symptoms.

Results: The median (interquartile range) vitamin D level was 24.6 (20.0–29.0) ng/mL. Hypovitaminosis D (<30 ng/mL) was observed in 80.0% (95% CI: 71.3%–87.0%) respondents. Patients who had difficulty in climbing stairs, bone pain and muscle cramp had 79.8%, 84.9% and 79.8% hypovitaminosis D respectively. In logistic regression analysis, overweight defined by body mass index ≥25 kg/m2 (OR 5.5, 95% CI 1.7–17.4) was significantly associated with hypovitaminosis D.

Conclusions: Hypovitaminosis D was common in patients with unexplained MSK symptoms and overweight was significantly associated with it. Further studies in representative samples are necessary.

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Published

2023-12-07

How to Cite

Razzaque, M. A., Bandhan, I. H., Bhuiyan, R., Haider, M. Z., Karim, M. N., & Choudhury, M. R. (2023). Vitamin D level among patients with unexplained musculoskeletal symptoms. Bangabandhu Sheikh Mujib Medical University Journal, 16(4). https://doi.org/10.3329/bsmmuj.v16i4.70186

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