Vitamin D supplementation on prediabetic adults with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial

Vitamin D supplementation on prediabetic adults with vitamin D deficiency

Authors

  • Md Habibul Ghani Junior consultant, Jinjira 20 beded Hospital, Keranigonj, Dhaka, Bangladesh
  • Md. Shahed Morshed Emergency Medical Officer, Kurmitola General Hospital, Dhaka, Bangladesh
  • Tahniyah Haq Assistant Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Shahjada Selim Associate Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Murshed Ahamed Khan Assistant Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Marufa Mustari Assistant Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Mostafa Hasan Rajib Medical Officer, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Anil Yadav Lecturer, Department of Internal Medicine (Endocrinology division), Biratnagar Medical College Teaching Hospital, Biratnagar, Nepal
  • Ibrahim Faisal Consultant, Indira Gandhi Memorial Hospital, Kanbaa Aisa Rani Higun, Male, Republic of Maldives
  • Anil Kumar Shah Senior lecturer, Chitwan Medical College, Chitwan, Nepal.
  • Md Firoj Hossain Assistant Professor, Department of Endocrinology, Mugda Medical College, Dhaka, Bangladesh.
  • M A Hasanat Professor, Department of Endocrinology, BSMMU, Dhaka, Bangladesh
  • Md Fariduddin Professor, Department of Endocrinology, BSMMU, Dhaka, Bangladesh.

DOI:

https://doi.org/10.3329/bsmmuj.v15i3.62956

Keywords:

Vitamin D, Prediabetes, Insulin resistance, Glycated hemoglobin A1C, HOMA-IR, High sensitivity C-reactive protein

Abstract

Hypovitaminosis D (<20 ng/mL) is thought to increase insulin resistance and meta-inflammation contributing to the pathogenesis of diabetes mellitus (DM). Correcting vitamin D deficiency in people with prediabetes might halt its progression to DM. The aim of this study was to examine the effect of vitamin D supplementation on insulin resistance, glycemic status, and inflammation in prediabetic adults with vitamin D deficiency. This doubleblind randomized placebo-controlled trial was done among 27 newly detected prediabetic adults with hypovitaminosis D randomly assigned to 60,000 IU of vitamin D weekly for eight weeks followed by monthly for the next four months or placebo along with lifestyle modification in both groups [vitamin D (n= 14) vs. Placebo (n=13). They were comparable in terms of sex, age and borlymass index. Glycemic status, fasting plasma glucose (FPG) and Hemoglobin A1C (HbA1C), insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR) and inflammatory marker high sensitivity C reactive protein (hs-CRP) were measured at baseline and after six months of intervention. Vitamin D levels (ng/mL) increased in both groups from baseline (vitamin D vs. placebo: 12.2±5.9 vs. 3.9±3.5, mean±SD). FPG (mmol/L) significantly decreased in the Vitamin D group (before vs. after: 5.9±0.6 vs. 5.5±0.7, P=0.016, mean±SD), whereas HbA1C (%) and hs- CRP (mg/L) significantly increased in the placebo group (before vs. after- HbA1C: 5.8±0.3 vs. 6.0±0.4, P<0.001; hs-CRP: 5.0±4.4 vs. 5.6±4.9, P=0.039, mean±SD). Percent changes in glycemic status, HOMA-IR, and hs-CRP were statistically similar between the groups. Our study failed to demonstrate the positive effects of vitamin D supplementation on reducing glucose, insulin resistance, or inflammatory marker in prediabetic adult patients with hypovitaminosis D.

BSMMU J 2022; 15(3): 167-174

Downloads

Download data is not yet available.
Abstract
120
PDF
112

Downloads

Published

2023-01-16

How to Cite

Ghani, M. H. ., Morshed, M. S. ., Haq, T. ., Selim, S. ., Khan, M. A. ., Mustari, M. ., Rajib, M. H. ., Yadav, A. ., Faisal, I. ., Shah, A. K. ., Hossain, M. F. ., Hasanat, M. A., & Fariduddin, M. (2023). Vitamin D supplementation on prediabetic adults with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial: Vitamin D supplementation on prediabetic adults with vitamin D deficiency. Bangabandhu Sheikh Mujib Medical University Journal, 15(3), 167–174. https://doi.org/10.3329/bsmmuj.v15i3.62956

Issue

Section

Original Articles

Most read articles by the same author(s)