Relation between serum vitamin B<sub>12</sub> level and duration of treatment with carbamazepine in epilepsy patients

  • Mohammad Tariqul Islam Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Khair M. Sobhan Department of Neurology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
  • Mahjabin Rahman Shawly Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Shafiqur Saleheen Department of Neurology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
  • Mohammad Masum Emran Department of Neurology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
  • M. A. Hannan Department of Neurology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
Keywords: Carbamazepine, Epilepsy, Vitamin B12

Abstract

Vitamin B12 levels in the serum of 58 epileptic patients receiving only carbamazepine for at least 6 months were measured. Same number of epilepsy patients with no history of taking antiepileptic medicine were taken as control. The mean level of vitamin B12 in carbamazepine-treated epileptic patients was 265.5 pg/mL whereas it was 478.3 pg/mL in control. Increased duration of treatment of carbamazepine in epilepsy caused significantly decreased level of serum vitamin B12 (Pearson correlation coefficient, r = -0.9, p<0.0001). In conclusion, serum vitamin B12 level significantly decreased in relation to duration of carbamazepine treatment in epileptic patients.

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Published
2016-12-10
How to Cite
Islam, M., Sobhan, K., Shawly, M., Saleheen, S., Emran, M., & Hannan, M. A. (2016). Relation between serum vitamin B<sub>12</sub&gt; level and duration of treatment with carbamazepine in epilepsy patients. Bangabandhu Sheikh Mujib Medical University Journal, 9(4), 223-226. https://doi.org/10.3329/bsmmuj.v9i4.30371
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Original Articles