Efficacy and tolerability of 0.1% tazarotene cream and 0.05% tretinoin cream in the treatment of acne vulgaris

  • Mohammad Habibur Rahman Department of Dermatology and Venereology, BSMMUJ, Dhaka
  • Md. Shahidullah Sikder Department of Dermatology and Venereology, BSMMUJ, Dhaka
  • Lubna Khondker Department of Dermatology and Venereology, BSMMUJ, Dhaka
Keywords: Acne vulgaris, Tazarotene, Tretinoin

Abstract

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that is seen primarily in adolescents.

Objective: To compare the efficacy of 0.1 % tazarotene cream and 0.05% tretinoin cream in the treatment of mild to moderate acne vulgaris.

Methods: A randomized controlled clinical trial was done in the department of Dermatol­ogy and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Results: At base line mean number of comedones in group A and group B was 12.77 ± 4.01 and 11.80 ± 3.93 respectively (p=0.350) and at final follow up 4.17 ± 4.02 and 3.47 ± 4.00(p=0.501). At base line mean number ofpapules in group A and group B was 17.30 ± 10.29 and 18.57 ± 13.88 respectively (p=0.690) and at final follow up 7.63 ± 8.08 and 7.73 ± 9.98 (p=0.966). At base line mean number of pustules in group A and group B was 0.50 ± 1.33 and 0.53 ± 1.28 respectively (p=0. 922) and at final follow up 0.07 ± 0.37 and 0.00 (p=0.326). At baseline mean of total acne score was 30.57 ± 13.62 and 30.90 ± 17.17 in group A and B(p=0.934) and at final follow up it was 11.87 ± 12.04 and 11.20 ± 13.85 respectively in group A and B(p=0.846). At 1st follow up 3.3% of both group got excellent response, at 2nd follow up 13.3% of group A and 30.0% of group B got excellent response, and at final follow up 56.7% of group A and 63.3% of group B achieved excel­lent response. About 73.33% oftretinoin treated patient and 60% oftazarotene treated did not experience any side effects.

Conclusion: It can be concluded that 0.1 % tazarotene cream and 0.05% tretinoin cream is individually effective and tolerability of 0.1 % tazarotene is comparable to 0.05% tretinoin in the treatment of mild to moderate acne vulgaris.

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Abstract
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Published
2016-07-26
How to Cite
Rahman, M., Sikder, M., & Khondker, L. (2016). Efficacy and tolerability of 0.1% tazarotene cream and 0.05% tretinoin cream in the treatment of acne vulgaris. Bangabandhu Sheikh Mujib Medical University Journal, 8(1), 24-29. https://doi.org/10.3329/bsmmuj.v8i1.28916
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Original Articles