Neonatal diabetes mellitus in an infant: A case report
Keywords:
NDM, Failure to thrive, HyperglycaemiaAbstract
Background: Diabetes presenting in infancy may have a monogenic cause. Although neonatal diabetes is usually diagnosed before 6 months of age, genetic evaluation may be relevant in older infants with atypical features.
Case summary: A 13-month-old girl presented with poor weight gain for six months and increased thirst for two months. She weighed 6 kg (−3.6 SDS) and was mildly dehydrated. Fasting glucose was 11.30 mmol/L, two-hour postprandial glucose was 18.40 mmol/L, and HbA1c was 12.2%. C-peptide was low at 0.31 ng/mL, GAD65 antibodies were negative, and urinary ketones were absent. Pancreatic ultrasonography was normal. She was treated with short-acting and long-acting insulin, with improvement in glucose levels. Genetic testing was advised but had not been completed.
Conclusion: Early-onset diabetes with poor growth, low C-peptide, and negative GAD65 antibodies raises suspicion for monogenic diabetes. Molecular testing is needed to establish the subtype and guide treatment. Because diabetes was detected at 13 months, a diagnosis of neonatal diabetes cannot yet be confirmed.
[J Assoc Clin Endocrinol Diabetol Bangladesh, 2026;5(Suppl 1): S77]
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Copyright (c) 2026 Samina Jahan Mitu, Md. Anowar Hossain, Ershad Mondal, Sohrab Hossain, Abdullah Al Ragib, Md. Abul Hasnat, ABM Kamrul Hasan
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