Screening before 24 weeks of gestation may be wise for early detection of abnormal glucose tolerance during pregnancy

Authors

  • Md Rakibul Hasan Associate Professor of Endocrinology, Medical College for Women and Hospital. Uttara Model Town, Dhaka, Bangladesh
  • Nusrat Sultana Assistant Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • Sandesh Panthi Consultant, Department of Endocrinology and Diabetes, Grande International Hospital, Kathmandu, Nepal
  • Mashfiqul Hasan Ph.D. student, Department of Endocrinology, BSMMU, Dhaka, Bangladesh
  • Sharmin Jahan Associate Professor of Endocrinology, BSMMU, Dhaka, Bangladesh
  • Muhammad Abul Hasanat Professor of Endocrinology, BSMMU, Bangladesh

DOI:

https://doi.org/10.3329/jacedb.v2i2.78441

Keywords:

Early pregnancy hyperglycemia, Gestational diabetes mellitus, Diabetes in pregnancy, Bangladesh

Abstract

Background: Screening for abnormal glucose tolerance (AGT) before 24 weeks of gestation (WG) is underestimated though its effects on pregnancy outcomes are not negligible.

Objectives: To see the frequency of AGT before 24WG and its correlation with maternal risk factors.

Methods: In this cross-sectional study, 451 pregnant women (gestational weeks 6-23) were enrolled from July 2013 to June 2017. Study participants underwent 75g OGTT (2 samples, n=451, 3 samples, n=249) to categorize them into normal glucose tolerance (NGT) or AGT following World Health Organization (WHO) criteria both 2013 and non-pregnant criteria. Glucose was measured by the glucose oxidase method.

Results: Overt diabetes and prediabetes were 24 (5.3%) and 132 (29.3%) respectively when WHO non-pregnant adult criteria were applied (n=451). Whereas, 11 (4.4%) and 68 (27.3%) were diabetes in pregnancy (DIP) and gestational diabetes mellitus (GDM) respectively according to WHO 2013 criteria (n=249). Age (27.60±4.82 vs. 25.43±4.64, years, p<0.001), BMI (25.90±4.41 vs. 23.56±3.85 kg/m2, p<0.001), systolic blood pressure (105.61±12.18 vs. 100.76±11.90 mm-Hg, p<0.001), diastolic blood pressure (68.75±8.95 vs. 64.85±8.47 mm-Hg, p <0.001) and family history of diabetes (53.8% vs. 35.0 %, p<0.001) were significantly higher in AGT than NGT (n=451). 02h plasma glucose value on OGTT had a positive correlation with age (r=0.268, p<0.001), BMI (r=0.277, p<0.001), and FPG (r=0.551, p<0.001). BMI (B=0.021, p<0.001, CI 95%: 0.010-0.032) was an independent predictor for AGT.

Conclusions: High prevalence of AGT was observed before 24WG, and needs careful attention to avoid complications.

J Assoc Clin Endocrinol Diabetol Bangladesh, July 2023;2(2): 39-45

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Published

2025-07-20

How to Cite

Hasan, M. R., Sultana, N., Panthi, S., Hasan, M., Jahan, S., & Hasanat, M. A. (2025). Screening before 24 weeks of gestation may be wise for early detection of abnormal glucose tolerance during pregnancy. Journal of Association of Clinical Endocrinologist and Diabetologist of Bangladesh, 2(2), 39–45. https://doi.org/10.3329/jacedb.v2i2.78441

Issue

Vol. 2 No. 2 (2023)

Section

Original Article

License

Copyright (c) 2023 Md Rakibul Hasan, Nusrat Sultana, Sandesh Panthi, Mashfiqul Hasan, Sharmin Jahan, Muhammad Abul Hasanat

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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