Comparison of radiation therapy alone and concurrent chemoradiation therapy for in operable cervical cancer

Authors

  • Md. Zillur Rahman Bhuiyan Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Atiar Rahman Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Sarwar Alam Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Towfiqul Hasan Firoz Departrnent of Radiation Oncology, National Institute of Cancer Research & Hospital
  • Sheikh Saiful Islam Shaheen Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Joly Bishwas Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v7i2.29295

Keywords:

Chemoradiation therapy, Inoperable cervical cancer, Radiotherapy

Abstract

Objectives: Concurrent chemoradiation therapy (CCRT) is the standard treatment for inoperable cervical cancer. The purpose of this study was to compare the outcomes of CCRT with cisplatin and radiotherapy (RT) for inoperable cervical cancer. Methods: From January 2O12 to June 2012, 60 female patients with FIGO stage IIB to IVA were enrolled in this randomized phase III trial to compare radiotherapy (RT) alone with chemo radiotherapy (RT 5 Fraction in a week and Cinplatin 40 mg weekly). External beam radiation therapy was delivered using a telecobalt-60 unit. This was followed by 21 Gy of intracavitary brachytherapy. Results: In total, 30 patients were recruited: RT alone (30) and CCRT (30). The age of patients ranged from 26-65 years. There was statistically significant (p value < 0.037) complete response (70.00%) CCRT group vs 43.30% RT group) in CCRT group. Conclusion: CCRT was seen to have better efficacy for patients with inoperable cervical cancer than RT alone.

 

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Author Biography

Md. Zillur Rahman Bhuiyan, Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

 

 

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Published

2016-08-24

How to Cite

Bhuiyan, M. Z. R., Rahman, A., Alam, S., Firoz, T. H., Shaheen, S. S. I., & Bishwas, J. (2016). Comparison of radiation therapy alone and concurrent chemoradiation therapy for in operable cervical cancer. Bangabandhu Sheikh Mujib Medical University Journal, 7(2), 84–90. https://doi.org/10.3329/bsmmuj.v7i2.29295

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Original Article

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