Epstein-Barr virus latent membrane protein-1 expression in Hodgkin lymphoma

  • Ferdousy Begum Department of Pathology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh
  • Prabir Kumar Saha Department of Pathology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh
  • Tasmina Enam Department of Pathology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh
  • Mohammed Kamal Department of Pathology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh

Abstract

Expression of latent membrane protein-1 of Epstein-Barr virus is documented in Hodgkin lymphoma indicating its relationship in disease process. A total of 50 cases of Hodgkin lymphoma were analyzed for latent membrane protein-1 expression by immunohistochemistry. The mean age was 28.7 years with male predominance. Mixed cellularity classical Hodgkin lymphoma was the commonest subtype (50% cases). Out of 50 cases, 48% cases were found positive for latent membrane protein. Of the five histologic subtypes, all cases of lymphocyte depleted classical Hodgkin lymphoma showed positivity which was followed by 60% positivity of mixed cellularity classical Hodgkin lymphoma. Association of latent membrane protein-1 expression in relation to different age group, site of involvement and subtypes of Hodgkin lymphoma were found statistically insignificant while latent membrane protein-1 expression was significantly higher in male than female.

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Published
2018-09-01
How to Cite
Begum, F., Saha, P., Enam, T., & Kamal, M. (2018). Epstein-Barr virus latent membrane protein-1 expression in Hodgkin lymphoma. Bangabandhu Sheikh Mujib Medical University Journal, 11(3), 203-208. https://doi.org/10.3329/bsmmuj.v11i3.36813
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Original Articles