Change in serum interleukin-6 levels in patients after pancreatoduodenectomy for periampullary cancer

Authors

  • Bidhan C. Das Department of Surgery, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • S. M. Khorshed Alam Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Zeba Fariha Nashid Department of Surgery, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Arif Salam Khan Department of Surgery, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Zulfiquer Rahman Khan Department of Surgery, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v10i1.31311

Keywords:

Interleukin-6, Pancreatoduodenectomy, Periampullary cancer

Abstract

This study was undertaken to elucidate the changes in interleukin-6 concentrations in the systemic circulation of 20 patients following pancreatoduodenectomy and whether it had any predictive value for postoperative complications. Blood was drawn on the day before surgery, at fixed intervals immediately after closure of the abdomen, and on day 1, 3, 5 after surgery for the measurement of interleukin-6. Change in the serum interleukin-6 levels was observed before and after pancreatoduodenectomy and between patients with and without complications. There was no mortality, but morbidity occurred in 5 patients. Serum interleukin-6 levels peaked immediately after surgery and gradually declined to preoperative level on postoperative day 5, but it remained persistently higher in a patient who developed postoperative complication. The peak level of interleukin-6 was significantly correlated with body mass index, duration of jaundice, biliary decompression prior to surgery, operation time and hospital stay, but not with operative blood loss. In conclusion, interleukin-6 is an important stress marker for predicting the complications after pancreatoduodenectomy operation. Patient with good body mass index status, short duration of jaundice and without preoperative biliary decompression provides less operative stress, less chance of complications and shorter hospital stay.

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Author Biography

Bidhan C. Das, Department of Surgery, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

 

 

Additional Files

Published

2017-02-23

How to Cite

Das, B. C., Alam, S. M. K., Nashid, Z. F., Khan, A. S., & Khan, Z. R. (2017). Change in serum interleukin-6 levels in patients after pancreatoduodenectomy for periampullary cancer. Bangabandhu Sheikh Mujib Medical University Journal, 10(1), 11–15. https://doi.org/10.3329/bsmmuj.v10i1.31311

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Section

Original Articles