Compound heterozygosity for hemoglobin D and hemoglobin E

Authors

  • Mohammad Mizanur Rahman Department of Hematology, Armed Forces Institute of Pathology, Dhaka Cantonment, Dhaka
  • Lutfunnahar Khan Department of Transfusion Medicine, Armed Forces Institute of Pathology, Dhaka Cantonment, Dhaka
  • Masuda Begum Department of Hematology, Faculty of Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Debashish Saha Department of Chemical Pathology, Armed Forces Institute of Pathology, Dhaka Cantonment, Dhaka
  • Arif Ahmed Khan Department of Microbiology, Armed Forces Institute of Pathology, Dhaka Cantonment, Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v9i4.30244

Keywords:

Compound heterozygosity, Hemoglobin D, Hemoglobin E

Abstract

We present two cases of compound heterozygous state for hemoglobin (Hb) D and HbE who reported to the hospital for fever and incidentally found moderate microcytic hypochromic anemia. Later on they were investigated by capillary hemoglobin electrophoresis. Capillary Hb electrophoresis revealed compound heterozygous state for hemoglobin D and hemoglobin E. On family screening, father of one patient turned out to be HbD trait and mother as HbE trait. Due to unavailability of parents and siblings of other patient, family screening was not possible. Compound or double heterozygous state for HbD and HbE is rare. There are only six published reported cases of such double heterozygous state for HbD and HbE in Southeast Asia. Marriage between third degree relatives, which are more common among Muslims as well as inter caste marriages, common in some states of India have resulted into this compound heterozygous condition. Such double heterozygous case is clinically silent as compared to HbE/beta thalassemia or HbD/beta thalassemia.

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Published

2016-12-09

How to Cite

Rahman, M. M., Khan, L., Begum, M., Saha, D., & Khan, A. A. (2016). Compound heterozygosity for hemoglobin D and hemoglobin E. Bangabandhu Sheikh Mujib Medical University Journal, 9(4), 214–216. https://doi.org/10.3329/bsmmuj.v9i4.30244

Issue

Section

Case Report

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