Serum concentration of folate, vitamin B<sub>12</sub> and homocysteine in patients of cervical cancer

  • Jannatul Ferdous Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Sabera Khatun Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Subrata Kumar Biawas Department of Biochemistry, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Latifa Akter Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Kashfia Ahmed Keya Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Keywords: Cervical cancer, Folate, Homocysteine, Vitamin B12

Abstract

The aim of this study was to evaluate the risk of cervical cancer in relation to serum concentration of folate, vitamin B12 and homocysteine. Fifty patients with invasive cervical cancer and 50 VIA negative cases (control) with age range of 30-65 years were included. Majority of the patients had significantly low level of serum folate and B12 than those in the control group.  In contrast, serum homocysteine level was significantly high in cases than those in the control group. The Pearson correlation coefficient test showed a significant negative relationship between serum folate, vitamin B12 and serum homocyteine. However, there was no significant association between stage of cervical cancer and level of serum homocysteine. In conclusion, a significantly low level of serum folate, vitamin B12 and high level of serum homocysteine were observed in patients with invasive cervical cancer.

Downloads

Download data is not yet available.
Abstract
796
Download
827 Read
378

Author Biographies

Jannatul Ferdous, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Associate Professor
Sabera Khatun, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Professor
Subrata Kumar Biawas, Department of Biochemistry, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Associate Professor
Latifa Akter, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Medical Officer
Kashfia Ahmed Keya, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Colposcoipist
Published
2016-12-05
How to Cite
Ferdous, J., Khatun, S., Biawas, S., Akter, L., & Keya, K. (2016). Serum concentration of folate, vitamin B<sub>12</sub&gt; and homocysteine in patients of cervical cancer. Bangabandhu Sheikh Mujib Medical University Journal, 9(4), 188-192. https://doi.org/10.3329/bsmmuj.v9i4.30104
Section
Original Articles