Leigh syndrome: A rare mitochondrial disorder

  • Gopen Kumar Kundu Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Amina Akhter Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Shaheen Akhter Institute of Paediatric Neuro-disorder & Autism, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Md. Mizanur Rhaman Institute of Paediatric Neuro-disorder & Autism, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Abstract

Leigh syndrome is a rare, mitochondrial disorder of childhood . In most cases dysfunction of the respiratory chain enzymes is responsible for the disease. Raised lactate levels in blood and/or cerebrospinal fluid is noted. Magnetic resonance imaging showing characteristic symmetrical necrotic lesions in the basal ganglia and/or brain stem that leads to the  appropriate diagnosis. Here, we report a case of progressive neurologic disorders presenting with motor and intellectual regression which on MRI was diagnosed as Leigh syndrome.

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Author Biographies

Gopen Kumar Kundu, Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Associate Professor

 

Amina Akhter, Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
MD Phase-B Student
Shaheen Akhter, Institute of Paediatric Neuro-disorder & Autism, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Professor and Project Director

Md. Mizanur Rhaman, Institute of Paediatric Neuro-disorder & Autism, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Professor
Published
2016-08-18
How to Cite
Kundu, G., Akhter, A., Akhter, S., & Rhaman, M. (2016). Leigh syndrome: A rare mitochondrial disorder. Bangabandhu Sheikh Mujib Medical University Journal, 9(2), 126-128. https://doi.org/10.3329/bsmmuj.v9i2.28889
Section
Case Reports