Diagnosing oral squamous cell carcinoma using salivary biomarkers

  • Mohammad Sayedur Rahman Khan Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
  • Fatama Siddika Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
  • Sun Xu Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
  • Xiao Lin Liu Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
  • Mei Shuang Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
  • Hao Fu Liang Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
Keywords: Biomarker, DNA marker, RNA marker, Protein marker, Saliva, Squamous cell carcinoma

Abstract

Oral cancer is becoming frightful public health issue because of its raising incidence as well as mortality rates worldwide. Out of all types of oral cancer, the oral squamous cell carcinoma is the most common malignant tumor with an incidence of about 90%. This fatal disease is diagnosed through a comprehensive clinical examination followed by the histological assessments forming the diagnostic gold standard. Although the oral cavity is simply accessible, but maximum oral cancers are usually diagnosed at the late stage. Consequently, it is necessary to implicate newer screening and early diagnosing approaches which will diminish the morbidity as well as mortality related to this disease. Saliva which is a complex biological fluid has a direct relation with the oral cancer lesion and contains abnormal DNA, RNA, protein molecules released by the malignant cells. These can be labelled as neoplastic biomarkers proposed to play an important role in diagnostic, therapeutic and prognostic purposes for oral cancers as well as other diseases. The aim of this review paper is to concisely discuss the different types of potential salivary biomarkers as well as their interaction for screening of oral cancers.

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Author Biographies

Mohammad Sayedur Rahman Khan, Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
Postgraduate student
Fatama Siddika, Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
Postgraduate student
Hao Fu Liang, Department of Oral and Maxillofacial Surgery, College of Stomatology, Hebei Medical University, Shijiazhuang, Hebei 050017
Professor
Published
2018-03-04
How to Cite
Khan, M. S., Siddika, F., Xu, S., Liu, X., Shuang, M., & Liang, H. (2018). Diagnosing oral squamous cell carcinoma using salivary biomarkers. Bangabandhu Sheikh Mujib Medical University Journal, 11(1), 1-10. https://doi.org/10.3329/bsmmuj.v11i1.35399
Section
Review Article