Association of serum vitamin D and parathormone levels in patients of type 2 diabetes mellitus with diabetic retinopathy

  • Mohammad Shiblee Zaman Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md. Matiur Rahman Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Subrata Kumar Biswas Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md. Mozammel Hoque Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Khondakar Alwan Nahid Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
Keywords: Diabetes mellitus, Diabetic retinopathy, Parathormone, Vitamin D

Abstract

The present study was aimed to evaluate the association of serum 25-hydroxy vitamin D and parathormone in 46 patients of type 2 diabetes mellitus with diabetic retinopathy [non-proliferative, (n=27); proliferative (n=19)]. Twenty one diabetic patients without retinopathy were taken as control. Serum 25-hydroxy vitamin D and intact parathyroid hormone were measured by chemiluminescence microparticle immunoassay. Concentration of 25-hydroxy vitamin D differed significantly among groups (p=0.018) and it was significantly lower in proliferative diabetic retinopathy than no diabetic retinopathy (p=0.003). Logistic regression analysis revealed that vitamin D deficiency [25-hydroxy vitamin D <20 ng/mL] was indepen-dently associated with development of diabetic retinopathy (p=0.007, OR 20.90, 95%CI 2.33-187.23). In conclusion, vitamin D deficiency is associated with diabetic retinopathy complicating type 2 diabetes mellitus.

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Author Biographies

Md. Matiur Rahman, Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
Associate Professor
Subrata Kumar Biswas, Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
Associate Professor
Md. Mozammel Hoque, Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
Professor and Chairman
Published
2017-05-22
How to Cite
Zaman, M., Rahman, M., Biswas, S., Hoque, M., & Nahid, K. (2017). Association of serum vitamin D and parathormone levels in patients of type 2 diabetes mellitus with diabetic retinopathy. Bangabandhu Sheikh Mujib Medical University Journal, 10(2), 61-65. https://doi.org/10.3329/bsmmuj.v10i2.32287
Section
Original Articles