Prediction of oesophageal varices in cirrhotic patients by measuring liver stiffness with fibroscan

  • Shahinul Alam Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Ahmed Lutful Moben Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • A.K.M. Kborshed Alam Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
Keywords: Cirrhosis, Fibroscan, Liver stiffness, Oesophageal varices

Abstract

Background: Repeated endoscopy is required to detect & follow up of esophageal varices (OV) in cirrhotic patients.

Objective: For discomfort and unwillingness lo do the endoscopy directed us to evaluate liver stiffness measurement (LSM) for lhe prediclion ofO V.

Methods: A cross sectional observational study was conducted between July 2010 to July 2011. A total of 50 patients with cirrhosis were divided into three groups. Group-I patients had no varix (n=4), group-II had Grade-I OV (n=23) and group-UI had Grade-II/III OV (n=23 ) at endoscopy. Liver stiffness was measured by fibroscan & data was analyzed by SPSS.

Results: Mean age were 35.20 ± 11.36 years with highest frequency 19 (38 %) in 21-30 years age group. Etiologies were different with leading causes includes HBV (76%) followed by HCV (6%), alcohol (2%) and 14% were unknown. Liver stiffness did not significantly differ from group-I & group-II, but was signifi­cantly higher in group III than group-II & group I. Liver stiffness was nol accurate in the prediction of grade-I oesophageal variees [Arca under the curve (AUC)] = 23.6%. Liver stiffness at a cut off value 32.52 kPa with sensitivity, specificity, positive predictive value, negative predictive value, accuracy respectively 82.6%, 77.8 %, 76 %, 84%, 80% can predict the Grade-II-Ill oesophageal varices (AUROC = 85.2%).

Conclusion: Liver stiffness may be suitable for prediction of Grade-II-III oesophageal varices, not for the screening of the presence of oesophageal varices.

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Abstract
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Published
2016-08-04
How to Cite
Alam, S., Moben, A., & Alam, A. (2016). Prediction of oesophageal varices in cirrhotic patients by measuring liver stiffness with fibroscan. Bangabandhu Sheikh Mujib Medical University Journal, 6(2), 85-89. https://doi.org/10.3329/bsmmuj.v6i2.29121
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Original Articles