Epitope-based vaccine as a universal vaccination strategy against Toxoplasma gondii infection: A mini-review

  • Khalid Hajissa Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Robaiza Zakaria Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • Rapeah Suppian Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia 16150 Kubang Kerian, Kelantan, Malaysia
  • Zeehaida Mohamed Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Keywords: Toxoplasma gondii; Epitope vaccine; DNA vaccines

Abstract

Despite the significant progress in the recent efforts toward developing an effective vaccine against toxoplasmosis, the search for new protective vaccination strategy still remains a challenge and elusive goal because it becomes the appropriate way to prevent the disease. Various exper­imental approaches in the past few years showed that developing a potential vaccine against the disease can be achievable. The combination of multi-epitopes expressing different stages of the parasite life cycle has become an optimal strategy for acquiring a potent, safe, and effective vaccine. Epitope-based vaccines have gained attention as alternative vaccine candidates due to their ability of inducing protective immune responses. This mini-review highlights the current status and the prospects of Toxoplasma gondii vaccine development along with the application of epitope-based vaccine in the future parasite immunization as a novel under development and evaluation strategy.

J. Adv. Vet. Anim. Res., 6(2): 174-182, June 2019

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Abstract
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Published
2019-06-13
How to Cite
Hajissa, K., Zakaria, R., Suppian, R., & Mohamed, Z. (2019). Epitope-based vaccine as a universal vaccination strategy against Toxoplasma gondii infection: A mini-review. Journal of Advanced Veterinary and Animal Research, 6(2), 174-182. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/41756
Section
Mini Review