Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone

  • Ivan A Arkhipov Department of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia
  • Salavat S Khalikov Department of Physiologically Active Organofluorine Compounds, A.N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Moscow, Russia
  • Konstantin M Sadov Department of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia
  • Alexander V Dushkin Department of Mechanochemistry of Organic Compounds, Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
  • Elizaveta S Meteleva Department of Mechanochemistry of Organic Compounds, Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
  • Anastasiya I Varlamova Department of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia
  • Irina M Odoevskaya Department of Experimental Therapy, All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants, Branch of Federal Scientific Center, All-Russian Scientific Research Institute of Experimental Veterinary Medicine K.I. Skryabin and Y.R. Kovalenko of the Russian Academy of Sciences, Moscow, Russia
  • Nataliya V Danilevskaya Department of Pharmacology and Toxicology, Moscow State Academy of Veterinary Medicine and Biotechnology, MVA named after K.I. Skryabin, Moscow, Russia
Keywords: Efficacy; fenbendazole; polyvinylpyrrolidone polymer; supramolecular complex; mechanochemistry.

Abstract

Objective: The purpose of our research was to evaluate the effect of mechanochemical technol­ogy on the efficacy of supramolecular complex of fenbendazole (SMCF) with polyvinylpyrrolidone (PVP) polymer against some helminthosis of animals.

Materials and Methods: The SMCF samples with PVP were synthesized using a solid-state mech­anochemical technology in activators of impact-abrading type and their physicochemical prop­erties were analyzed. The efficacy of SMCF was studied on the laboratory model of Hymenolepis nana and Trichinella spiralis infection of mice and helminthosis of sheep.

Results: In the trials conducted on laboratory models, the supramolecular complex showed 93.94% and 98.56 % efficacy at the dose of 1 mg/kg of body weight (b/w), while the substance of fenbendazole showed 7.97% and 8.33% efficacy at the same dose. A high efficacy (>94%) of the SMCF was revealed at the dose of 2.0 mg/kg of b/w at oral administration against nematodes in naturally infected sheep by the results of the fecal examination, while the substance of fenben­dazole was active at the dose of 5.0 mg/kg at single oral administration. Moreover, the SMCF demonstrated 97.37% efficacy at the dose of 2 mg/kg against Moniezia spp. infection of sheep. Physicochemical studies confirmed the increase in solubility of the complex, reducing of particle sizes, amorphization of fenbendazole substance, and incorporating it with micelles of PVP.

Conclusion: According to the results, supramolecular complex of fenbendazole with PVP was more active than the basic substance of fenbendazole and its anthelmintic properties were expanded.

J. Adv. Vet. Anim. Res., 6(1): 133-141, March 2019

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Published
2019-03-31
How to Cite
Arkhipov, I., Khalikov, S., Sadov, K., Dushkin, A., Meteleva, E., Varlamova, A., Odoevskaya, I., & Danilevskaya, N. (2019). Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone. Journal of Advanced Veterinary and Animal Research, 6(1), 133-141. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/40849
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Original Articles