Emergence of colistin resistance in extended-spectrum beta lactamase producing Enterobacteriaceae isolated from food animals and its public health implication: A review

  • Asinamai Athliamai Bitrus
  • Rungtip Chuanchuen
  • Taradon Luangtongkum
Keywords: Antimicrobial resistance, Colistin, Emergence, Extented-spectrum, mcr-1

Abstract

Antimicrobial resistance as a result of emergence of extended-spectrum beta lactamase producing Enterobacteriaceae is a major health problem of human and animal that requires an intensive global attention. The production of beta lactamase enzymes remains as one of the major factors contributing to the development of resistance to beta lactams. These enzymes hydrolyze the beta lactam ring of the antibiotic and render it ineffective. Extended-spectrum beta lactamase producing bacteria have the ability to develop resistance to a number of antibiotics including the carbapenem and other third generation cephalosporins. In addition, the recent emergence and dissemination of the colistin resistance determinants mcr-1, mcr-2 and mcr-3 poses a serious threat to colistin as a drug of last resort in human medicine. In this review, we utilized words such as “colistin resistance and Escherichia coli”, “Klebsiella and colistin resistance”, “colistin resistance and Salmonella” as well as “detection of mcr-1 genes in Salmonella and E. coli”. The extended-spectrum beta lactamase producing bacteria under Enterobacteriaceae that are resistant to colistin possess the ability to be transferred resistant determinants to other susceptible cells at a higher frequency. In this paper, the role of manure from food animals and how air travel contributes to the dissemination of mcr-1 haboring bacteria, resistance determinants and other metabolites that constitute a public health problem was also reviewed. It is concluded that these pathogens have significant consequences to the control of infection and  plays key roles in treatment failure with colistin.

http://doi.org/10.5455/javar.2018.e246    

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Author Biographies

Asinamai Athliamai Bitrus

Department of Veterinary Public health, Faculty of Veterinary science, Chulalongkorn University, 10330 Pathumwan Bangkok, Thailand.

Rungtip Chuanchuen
Department of Veterinary Public health, Faculty of Veterinary science, Chulalongkorn University, 10330 Pathumwan Bangkok, Thailand.
Taradon Luangtongkum
Department of Veterinary Public health, Faculty of Veterinary science, Chulalongkorn University, 10330 Pathumwan Bangkok, Thailand.
Published
2018-04-04
How to Cite
Bitrus, A. A., Chuanchuen, R., & Luangtongkum, T. (2018). Emergence of colistin resistance in extended-spectrum beta lactamase producing Enterobacteriaceae isolated from food animals and its public health implication: A review. Journal of Advanced Veterinary and Animal Research, 5(1), 1-11. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/36082
Section
Review Articles