Experimental intraocular infection of exotic cockerels with field strain of velogenic Newcastle disease virus in Nigeria

Authors

  • Samaila Jonathan Badau Department of Veterinary Pathology, Faculty of Veterinary Medicine (FVM), University of Maiduguri, PMB 1069, Maiduguri
  • Shehu Usman Hassan Department of Veterinary Pathology, Faculty of Veterinary Medicine (FVM), University of Maiduguri, PMB 1069, Maiduguri
  • Abdul-Dahiru El-Yuguda Department of Veterinary Microbiology and Parasitology, FVM, University of Maiduguri, PMB 1069, Maiduguri
  • Ikechukwu Onyebuchi Igbokwe Department of Veterinary Pathology, Faculty of Veterinary Medicine (FVM), University of Maiduguri, PMB 1069, Maiduguri

Keywords:

Chickens, intraocular infection, Newcastle disease, Nigerian NDV strain, velogenic virus, viscerotropic virus

Abstract

Experimental  intraocular  (conjunctival)  infection  of
exotic  cockerels  with  a  new  field  strain  of
viscerotropic  velogenic  Newcastle  Disease  Virus
(NDV)  was  conducted  to  explore  the  concurrence  of
some  pathological  changes  with  humoral  immune
responses.  After  the  NDV  infection  of  4-week-old
cockerels, pathologic changes and antibody responses
were  observed.  The  clinical  signs  observed  after  the
artificial  inoculation  included  inappetence,
depression,  diarrhea,  dyspnea,  wing  and  leg
paralysis,  torticollis  and  weight  loss.  Morbidity  due
to the NDV was 100%, but mortality was 80% by day
18-21 post-infection. Early hyperthermia followed by
terminal hypothermia, decreased packed cell volume
(PCV),  and  231.4  folds  peak-antibody  response  were
observed. Necrotic and/or inflammatory lesions were
present in the proventriculus, intestine, liver, spleen,
kidney  and  brain.    Neurologic  and  digestive  tract
perturbations  occurred  in  10%  and  85%  of  cases,
respectively. The disease consistently caused stunted
growth,  decreased  PCV,  and  necro-inflammatroy
lesions  concurrent  with  antibody  response,
suggesting  probable  involvement  of  immune-
mediated  mechanisms  and  cell  membrane
desialylation  by  viral  neuraminidase  in  the
pathogenesis.

http://dx.doi.org/10.5455/javar.2015.b111  

 

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Published

2015-12-31

How to Cite

Badau, S. J., Hassan, S. U., El-Yuguda, A.-D., & Igbokwe, I. O. (2015). Experimental intraocular infection of exotic cockerels with field strain of velogenic Newcastle disease virus in Nigeria. Journal of Advanced Veterinary and Animal Research, 2(4), 418–426. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/26090

Issue

Vol. 2 No. 4 (2015)

Section

Original Articles

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