Changes in Serum Calcium, Albumin and Alkaline Phosphatase Levels of Postmenopausal Women

Authors

  • Kamana Rani Saha Associate Professor, Department of Biochemistry, Community Based Medical College Hospital, Mymensingh, Bangladesh
  • Susmita Das Lecturer, Department of Biochemistry, Community Based Medical College Hospital, Mymensingh, Bangladesh
  • Shahidul Islam Associate Professor, Department of Dermatology and Venereology, Community Based Medical College Hospital, Mymensingh, Bangladesh
  • AHM Hasan Associate Professor, Department of Community Medicine, Community Based Medical College Hospital, Mymensingh, Bangladesh
  • Rafika Afrose Associate Professor (CC), Department of Pharmacology, Community Based Medical College Hospital, Mymensingh, Bangladesh
  • Md Abdur Razzaque Mia Professor, Department of Biochemistry, President Abdul Hamid Medical College Hospital, Kishorgong, Bangladesh

DOI:

https://doi.org/10.3329/cbmj.v8i2.55769

Keywords:

Menopause, serum calcium and albumin, alkaline phosphatase, osteoporosis

Abstract

A case-control cross-sectional study was carried out to observe the changes in serum calcium, albumin and alkaline phosphatase levels of postmenopausal women compared to their premenopausal counterparts. This is to enable us ascertain the relative risk of developing osteoporosis in postmenopausal women in Bangladesh. One hundred and eighteen (118) apparently healthy females (59 premenopausal=control and 59 postmenopausal=case) were selected for the study. The study was carried out in the Department of Biochemistry, Mymensingh Medical College in cooperation with the Department of Gynecology, Mymensingh Medical College Hospital and Community Based Medical College Hospital Bangladesh during the period from January to December 2009. Data were collected through clinical evaluation from pre-selected questionnaires. Fasting venous blood samples were taken for laboratory investigations. Serum calcium and albumin was determined using colorimetric method and enzymatic end point method was used to determine serum alkaline phosphatase levels. Statistical significance of difference between two groups were evaluated by using Student's unpaired 't' test with the help of SPSS software package. The results showed statistically significant decrease in serum calcium and albumin (p<0.01) of menopausal women compared to reproductive age group. The postmenopausal women had significantly higher (p<0.01) concentrations of serum alkaline phosphatase than the premenopausal women with regular menstruation. Therefore, it can be concluded that menopause leads to the increased risk of osteoporosis by decreasing serum calcium and albumin and by increasing alkaline phosphatase levels. The decreased serum calcium and increased alkaline phosphatase levels indicate that menopause is an independent risk factor for developing osteoporosis in women of Bangladesh.

CBMJ 2019 July: Vol. 08 No. 02 P: 30-35

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Published

2019-08-05

How to Cite

Saha, K. R. ., Das, S. ., Islam, S. ., Hasan, A., Afrose, R., & Mia, M. A. R. . (2019). Changes in Serum Calcium, Albumin and Alkaline Phosphatase Levels of Postmenopausal Women. Community Based Medical Journal, 8(2), 30–35. https://doi.org/10.3329/cbmj.v8i2.55769

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Section

Original Articles