Forced swim test in mice: A common animal model of depression

Authors

DOI:

https://doi.org/10.3329/bjp.v11i1.25692

Keywords:

Antidepressants, Depression, Forced swim test

Abstract

The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential antidepressant-like medications. In this model the mice are put in a plexiglas tank. The tank is loaded with water and the behavior of the mice to escape the tank is scored. The behavioral parameter scored in this test is called immobility, resembling a behavioral state of misery, as seen in human depression.

Video Clip of Methodology

Pre-experiment:  50 sec   Full Screen   Alternate

Experiment: 7 min 12 sec   Full Screen   Alternate

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Author Biography

Muhammad Aslam, Department of Basic Medical Sciences, Faculty of Pharmacy, Ziauddin University, Karachi 75600

Research Scholar

References

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Liao J, Tsai J, Liu C, Huang H, Wu L, Peng W. Antidepressant-like activity of turmerone in behavioural despair tests in mice. BMC Complement Altern Med. 2013; 13: 299.

Rodrigues A, da Silva G, Mateussi A, Fernandes E, Miguel O, Yunes R, Calixto J, Santos A. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci. 2002; 70: 1347-58.

Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: A new method for screening anti-depressants in mice. Psychopharmacology 1985; 85: 367-70.

Suzuki E, Yagi G, Nakaki T, Kanba S, Asai M. Elevated plasma nitrate levels in depressive states. J Affect Disord. 2001; 63: 221-24.

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Published

2015-12-16

How to Cite

Aslam, M. “Forced Swim Test in Mice: A Common Animal Model of Depression”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Dec. 2015, pp. 28-29, doi:10.3329/bjp.v11i1.25692.

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Section

Visual Experiment