Hepatoprotective effect of Monotheca buxifolia fruit against antitubercular drugs-induced hepatotoxicity in rats

  • Irfan Ullah Department of Pharmacy, University of Peshawar, Peshawar http://orcid.org/0000-0002-8761-8879
  • Jamshaid Ali Khan Department of Pharmacy, University of Peshawar, Peshawar
  • Achyut Adhikari HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi
  • Muhammad Shahid Department of Pharmacy, University of Peshawar, Peshawar
Keywords: Antitubercular drug, Hepatoprotective, Hepatotoxicity, Monotheca buxifolia

Abstract

The present study investigates the hepatoprotective potential of Monotheca buxifolia fruit hydro-ethanolic extract, against isoniazid- and rifampicin- induced hepatotoxicity in rats. Phytochemical investigations lead to the isolation of oleanolic acid and isoquercetin. Pretreatment with M. buxifolia extract at doses of 150 and 300 mg/kg for 21 days, restored the isoniazid- and rifampicin-induced elevation of serum levels of alanine aminotransferase (p<0.001), aspartate aminotransferase (p<0.001 and p<0.05), alkaline phosphatase (p<0.001), billirubin (p<0.001) and total proteins (p<0.001) as well as afforded significant protection against histopathological changes in the liver. From these results, it is conceivable that M. buxifolia exhibited selective protective effect against isoniazid- and rifampicin-induced hepatotoxicity, mediated through the presence of oleanolic acid and isoquercetin.

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Author Biography

Jamshaid Ali Khan, Department of Pharmacy, University of Peshawar, Peshawar
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Published
2016-01-26
How to Cite
Ullah, I., J. Khan, A. Adhikari, and M. Shahid. “Hepatoprotective Effect of Monotheca Buxifolia Fruit Against Antitubercular Drugs-Induced Hepatotoxicity in Rats”. Bangladesh Journal of Pharmacology, Vol. 11, no. 1, Jan. 2016, pp. 248-56, doi:10.3329/bjp.v11i1.25289.
Section
Research Articles