Evaluation of possible mechanisms of three plants for blood glucose control in diabetes


  • Damayanthi Dalu Department of Pharmacology, Netaji institute of Pharmaceutical Science, Toopranpet, Choutuppal, Nalgonda 508252, Telangana http://orcid.org/0000-0002-2407-822X
  • Satyavati Dhulipala Department of Pharmacology, Brilliant College of Pharmacy, Abdullapurmet, Hayatnagar, Ranga reddy, Hyderabad 501505,Telangana




Cocculus orbiculatus, Diabetes, Leea indica, Ventilago maderaspatana


This study was conducted to provide the evidence for the mechanism of  anti-diabetic activity of Cocculus orbiculatus, Leea indica and Ventilago maderaspatana. This was accomplished by employing methods like uptake of glucose, glycogen synthesis and inhibition of ?-glucosidase. For uptake of glucose, diaphragms were dissected out in Tyrode solution with 2% glucose and assayed for glucose content. In glycogen synthesis methodology liver, skeletal muscle and cardiac muscles were isolated, homogenized and glycogen content was analyzed. In ?-glucosidase enzyme inhibition procedure involved estimation of ?-glucosidase enzyme inhibition. All the three plant extracts exhibited significant (p<0.05 - p<0.01) anti-diabetic activity by increasing glucose uptake, glycogen synthesis and inhibiting ?-glucosidase enzyme. Among the three plants, V. maderaspatana (500 mg/kg) exhibited higher glucose uptake, glycogen content and ?-glucosidase inhibition activity (IC50 145 µg/mL). The present experimental results evidenced the anti-diabetic activity of three plants by all the three mechanisms.


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Author Biographies

Damayanthi Dalu, Department of Pharmacology, Netaji institute of Pharmaceutical Science, Toopranpet, Choutuppal, Nalgonda 508252, Telangana

Assosciate Professor

Satyavati Dhulipala, Department of Pharmacology, Brilliant College of Pharmacy, Abdullapurmet, Hayatnagar, Ranga reddy, Hyderabad 501505,Telangana



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How to Cite

Dalu, D., and S. Dhulipala. “Evaluation of Possible Mechanisms of Three Plants for Blood Glucose Control in Diabetes”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Jan. 2016, pp. 224-30, doi:10.3329/bjp.v11i1.24932.



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