Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

Authors

  • Gino A. Kurian Department of Biochemistry, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu

DOI:

https://doi.org/10.3329/bjp.v11i2.24855

Keywords:

Diabetes, Hypoglycemic, Poly-herbal, Streptozotocin

Abstract

The present study evaluates the combinatorial effect of a poly-herbal combination with multiple therapeutic effects as a hypoglycemic and hypolipidemic agent. Herbal combination of Salacia oblonga, Tinospora cordifolia, Emblica officinalis, Curcuma longa and Gymnema sylvestre was prepared and administered to streptozotocin (55 mg/kg, i.p.)-induced diabetic rats, at a dose of 100 mg/kg, for four weeks. The poly-herbal combination significantly elevated the plasma insulin (90%) and reduced serum glucose (42%), cholesterol (49%), triglycerides (43%), LDL cholesterol (62.5%) and plasma apo B/apo A in the diabetic rats. The liver lipogenic enzymes like HMG CoA reductase and glucose-6-phosphatase significantly declined (p<0.05) in their activity while glucose-6-phosphate dehydrogenase and malic enzymes showed higher activity compared to the diabetic control. The results suggest a significant hypoglycemic and hypolipidemic property for the poly-herbal combination.

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Author Biography

Gino A. Kurian, Department of Biochemistry, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu

Senior Assistant Professor

 

 

Published

2016-03-21

How to Cite

Kurian, G. A. “Hypoglycemic Effect of Poly-Herbal Combination in Streptozotocin-Induced Diabetic Rats”. Bangladesh Journal of Pharmacology, vol. 11, no. 2, Mar. 2016, pp. 364-71, doi:10.3329/bjp.v11i2.24855.

Issue

Section

Research Articles