Antimalarial efficacy of nine medicinal plants traditionally used by the Karens of Andaman and Nicobar Islands, India

Authors

  • M. Punnam Chander Department of Medical Microbiology and Molecular Biology, Regional Medical Research Centre (Indian Council of Medical Research), WHO Collaborating Centre for Diagnosis, Reference, Research and Training in Leptospirosis, Port Blair 744 101, Andaman and Nicobar Islands http://orcid.org/0000-0003-0628-3227
  • C. R. Pillai Parasitology Bank, National Institute of Malaria Research (Indian Council of Medical Research), New Delhi http://orcid.org/0000-0002-3093-3405
  • P. Vijayachari Department of Medical Microbiology and Molecular Biology, Regional Medical Research Centre (Indian Council of Medical Research), WHO Collaborating Centre for Diagnosis, Reference, Research and Training in Leptospirosis, Port Blair 744 101, Andaman and Nicobar Islands http://orcid.org/0000-0002-4939-3875

DOI:

https://doi.org/10.3329/bjp.v11i1.24055

Keywords:

Andaman, Antimalarial, Nicobar Islands

Abstract

The aim of this study was to assess the antimalarial activity of nine medicinal plants used by Karens of Andaman and Nicobar Islands, against Plasmodium falciparum chloroquine-sensitive MRC-2 isolate. The methanol extracts were obtained by cold percolation method and in vitro antimalarial activity was assessed using M-III method. The results indicated that out of nine plant species tested, four plants, viz., Z. spectabilis, S. wallichiana, C. pulcherrima and Amomum sp. demonstrated significant antimalarial activity (50% inhibitory concentration values were 5.5 ± 0.7, 12.0 ± 2.5, 14.6 ± 1.3 and 37.3 ± 2.5 ?g/mL respectively) with no toxicity effect on erythrocytes.

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Author Biographies

M. Punnam Chander, Department of Medical Microbiology and Molecular Biology, Regional Medical Research Centre (Indian Council of Medical Research), WHO Collaborating Centre for Diagnosis, Reference, Research and Training in Leptospirosis, Port Blair 744 101, Andaman and Nicobar Islands

Research Scholar

 

C. R. Pillai, Parasitology Bank, National Institute of Malaria Research (Indian Council of Medical Research), New Delhi

Scientist

 

P. Vijayachari, Department of Medical Microbiology and Molecular Biology, Regional Medical Research Centre (Indian Council of Medical Research), WHO Collaborating Centre for Diagnosis, Reference, Research and Training in Leptospirosis, Port Blair 744 101, Andaman and Nicobar Islands

Director

 

Additional Files

Published

2015-12-21

How to Cite

Chander, M. P., C. R. Pillai, and P. Vijayachari. “Antimalarial Efficacy of Nine Medicinal Plants Traditionally Used by the Karens of Andaman and Nicobar Islands, India”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Dec. 2015, pp. 126-9, doi:10.3329/bjp.v11i1.24055.

Issue

Section

Research Articles