Inhibition of cell proliferation in gastric cancer cell lines on exposure to rubriflordilactone A

Authors

  • Shang-Jin Peng Department of General Surgery, Jinshan Hospital of Fudan University, Shanghai 201508
  • Jue-Wei Chen Department of Burns and Plastic Surgery, Jinshan Hospital of Fudan University, Shanghai 201508 http://orcid.org/0000-0003-4912-0786

DOI:

https://doi.org/10.3329/bjp.v11i1.23772

Keywords:

Cell proliferation, Gastric cancer cell line, Rubriflordilactone A

Abstract

The present study investigates the effect of rubriflordilactone A on the viability and its underlying mechanism in gastric cancer cell lines (SNU-1 and SNU-5) and normal gastric epithelial cell line (GES?1). Incubation of the gastric cancer and non cancer cell lines in acidic media led to reduction in the viability of the non cancer cells without any effect on cancer cells. Apoptosis in SNU-1 and SNU-5 cells was induced on exposure to rubriflordilactone A after 48 hours compared to the control cells (p<0.01). The percentage of apoptosis in SNU-1 and SNU-5 cells on exposure to rubriflordilactone A was 79.3 ± 4.7 and 74.0 ± 5.1, respectively after 48 hours. Exposure of SNU-1 and SNU-5 cancer cell lines to rubriflordilactone A at a concentration of 10 ?M in media with acidic pH decreased phosphorylation of ERK ½. The similar reduction was caused by ERK 1/2 phosphorylation inhibition, PD98059. Thus rubriflordilactone A reduces viability of gastric cancer cell lines by inducing apoptosis through the reduction of ERK 1/2 phosphorylation.

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Published

2015-12-17

How to Cite

Peng, S.-J., and J.-W. Chen. “Inhibition of Cell Proliferation in Gastric Cancer Cell Lines on Exposure to Rubriflordilactone A”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Dec. 2015, pp. 63-66, doi:10.3329/bjp.v11i1.23772.

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Section

Research Articles