In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

Authors

  • Bhawna Sharma Department of Pharmacology, College of Pharmacy, PDM Group of Institution, Bahadurgarh, Haryana, India
  • Isha Dhamija Department of Pharmacology, College of Pharmacy, PDM Group of Institution, Bahadurgarh, Haryana, India
  • Sandeep Kumar Department of Pharmacology, College of Pharmacy, PDM Group of Institution, Bahadurgarh, Haryana, India
  • Hema Chaudhary Department of Pharmacology, College of Pharmacy, PDM Group of Institution, Bahadurgarh, Haryana, India

DOI:

https://doi.org/10.3329/bjp.v10i2.22334

Keywords:

Anti-oxidant, Argyreia nervosa, Ehrlich Ascites Carcinoma, Liquid tumor

Abstract

The herb of importance like Argyreia nervosa has shown wide range of pharmacological activities. Its methanolic extract of A. nervosa has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15th day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p<0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days.  From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.

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Published

2015-05-04

How to Cite

Sharma, B., I. Dhamija, S. Kumar, and H. Chaudhary. “In Vitro and in Vivo Evaluation of Antitumor Activity of Methanolic Extract of Argyreia Nervosa Leaves on Ehrlich Ascites Carcinoma”. Bangladesh Journal of Pharmacology, vol. 10, no. 2, May 2015, pp. 399-08, doi:10.3329/bjp.v10i2.22334.

Issue

Section

Research Articles