Impact of Bone Growth Stimulants on Bone Regeneration in Dental Implantology: A Meta-Analysis

Authors

  • Niladri Maiti Central Asian University, School of Dentistry, Tashkent 111221, Uzbekistan
  • Riddhi Chawla Central Asian University, School of Dentistry, Tashkent 111221, Uzbekistan
  • Ahmad Danish Rehan Professor and Head, Oral Pathology and Microbiology and Forensic Odontology Department of Dentistry, Zoram Medical College, Falkawn, Mizoram 796005, India
  • Ataul Hafeez Imran BDS, MDS (Conservative Dentistry and Endodontics), FICOI (USA), Fellowship in Laser Dentistry (WCLI, USA), Private Practitioner, Noor Hospital, Qadian, District Gurdaspur, Punjab 143516, India
  • Jaiganesh Ramamurthy Professor, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India
  • Shipha Hegde Department of Prosthodontics, Crown & Bridge, A.B. Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru 575018, Karnataka, India

DOI:

https://doi.org/10.3329/bjms.v25i10.86621

Keywords:

bone regeneration; dental implants; growth substances; osseointegration; meta-analysis

Abstract

Bone growth stimulants (BGS) are increasingly used to enhance osseointegration in dental implants, but their efficacy remains debated. This meta-analysis evaluates the impact of BGS on bone regeneration and implant success. Following PRISMA guidelines, 25 studies (2000–2024) were analyzed. Random-effects models pooled effect sizes for outcomes like bone density and implant survival. Subgroup analyses compared graft types (autografts, alloplastics, bio-enhanced grafts). BGS improved osseointegration (pooled ES: 1.22, 95% CI: 0.95– 1.50), with bio-enhanced grafts showing the highest efficacy (ES: 1.43). Bioactive coatings (ES: 1.26) outperformed strontium coatings (ES: 0.94), while bisphosphonates negatively impacted outcomes (ES: -1.96). Heterogeneity was low (I² = 9.08%), but publication bias was detected (Egger’s test: *p* = 0.025). BGS, especially combination grafts, enhance implant stability, though patient-specific factors must guide clinical use.

Bangladesh Journal of Medical Science Vol. 25. Supplementary Issue 2026, Page : S36-S49

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Author Biographies

Niladri Maiti, Central Asian University, School of Dentistry, Tashkent 111221, Uzbekistan

 

 

Riddhi Chawla, Central Asian University, School of Dentistry, Tashkent 111221, Uzbekistan

 

 

Ahmad Danish Rehan, Professor and Head, Oral Pathology and Microbiology and Forensic Odontology Department of Dentistry, Zoram Medical College, Falkawn, Mizoram 796005, India

 

 

Ataul Hafeez Imran, BDS, MDS (Conservative Dentistry and Endodontics), FICOI (USA), Fellowship in Laser Dentistry (WCLI, USA), Private Practitioner, Noor Hospital, Qadian, District Gurdaspur, Punjab 143516, India

 

 

Jaiganesh Ramamurthy, Professor, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India

 

 

Shipha Hegde, Department of Prosthodontics, Crown & Bridge, A.B. Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru 575018, Karnataka, India

 

 

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Published

2026-01-06

How to Cite

Maiti, N., Chawla, R., Rehan, A. D., Imran, A. H., Ramamurthy, J., & Hegde, S. (2026). Impact of Bone Growth Stimulants on Bone Regeneration in Dental Implantology: A Meta-Analysis. Bangladesh Journal of Medical Science, 25(10), S36-S49. https://doi.org/10.3329/bjms.v25i10.86621

Issue

Vol: 25. Supplementary issue 2026

Section

Review Article

License

Copyright (c) 2026 Niladri Maiti, Riddhi Chawla, Ahmad Danish Rehan, Ataul Hafeez Imran, Jaiganesh Ramamurthy, Shipha Hegde

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