Exploring the Differences in Serum Amylase Levels among Obese and Non-obese Individuals with Type 2 Diabetes Mellitus

Authors

  • Deepa K Assistant Professor, Department of Biochemistry, Mysore Medical College & Research Institute Mysore, Karnataka, India
  • Sudhir Assistant Professor, Department of Community Medicine, Mandya Institute of Medical Sciences, Mandya, Karnataka, India
  • B K Manjunatha Goud Professor and Chairperson, Department of Biochemistry, RAKCOMS, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE
  • Akshatha L 3rd year MBBS student, Mysore Medical College & Research Institute, Mysore, Karnataka, India
  • Shubha Jayaram Professor & Head, Department of Biochemistry, Mysore Medical College & Research Institute, Mysore, Karnataka, India
  • Imran Rangraze Professor, Department of Internal Medicine, RAKCOMS, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE

DOI:

https://doi.org/10.3329/bjms.v25i1.86411

Keywords:

Type 2 diabetes; Obese; Serum amylase; Lipid profile

Abstract

Background The pancreas is a double-entity organ, and previous studies have shown that a significant proportion of patients with diabetes mellitus and obesity have pancreatic exocrine insufficiency (PEI). Increased risks of metabolic disorders, metabolic syndrome, and diabetes were linked to low serum amylase levels. Methodology Study population was be taken from patients visiting to K.R Hospital, Mysore with type-2 diabetes mellitus for follow up and they are grouped into two, based on their BMI as obese diabetics & non-obese Diabetics. Result The present study showed statistically decreased Serum Amylase in obese diabetics when compared with non-obese type 2 diabetic and increased Total Cholesterol/ HDL ratio. Present study also shows increased serum Triglyceride, Total cholesterol, LDL, VLDL in obese diabetic when compared with nonobese type 2 diabetes but not statistically significant. The study showed negative correlation between Serum Amylase with blood glucose & serum HDL but not statistically significant. Conclusion The current study findings suggest that lower serum amylase levels in obese people with type 2 diabetes may be linked to an exocrine-endocrine axis disruption, which impairs exocrine pancreatic function. This could then be utilized as a potential marker to evaluate the exocrine functions of the pancreas.

BJMS, Vol. 25 No. 01 January’26 Page : 125-135

 

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Author Biography

Deepa K, Assistant Professor, Department of Biochemistry, Mysore Medical College & Research Institute Mysore, Karnataka, India

 

 

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Published

2026-01-26

How to Cite

K, D., Sudhir, Goud, B. K. M., L, A., Jayaram, S., & Rangraze, I. (2026). Exploring the Differences in Serum Amylase Levels among Obese and Non-obese Individuals with Type 2 Diabetes Mellitus. Bangladesh Journal of Medical Science, 25(1), 125–135. https://doi.org/10.3329/bjms.v25i1.86411

Issue

Vol. 25 No. 1 (2026)

Section

Original Articles

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Copyright (c) 2026 Deepa. K , Sudhir , B K Manjunatha Goud, Akshatha L., Shubha Jayaram, Imran Rangraze

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