Comparison the effects of two different dose of intrathecal morphine adjunct to ultra-low dose of naloxone on pain intensity after cesarean section: A double-blind randomized clinical trial

Authors

  • Mohammad Reza Habibi Department of Anesthesiology, Faculty of Medicine, Cardiovascular Research Center, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  • Zohreh Ghahari Department of Anesthesiology, Faculty of Medicine, Cardiovascular Research Center, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  • Ali Habibi Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Afshin Gholipour Baradari Department of Anesthesiology, Faculty of Medicine, Cardiovascular Research Center, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  • Saloumeh Peivandi Department of Obstetrics and Gynecology, Faculty of Medicine, Clinical Research Development Unit of Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran and Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran

DOI:

https://doi.org/10.3329/bjms.v24i4.84684

Keywords:

Morphine; naloxone; cesarean section; nause

Abstract

Objective The aim of this study was to evaluate and compare the effects of two different dose of intrathecal morphine adjunct to ultra-low dose of naloxone on pain intensity after cesarean section. Methods In this double-blind randomized clinical trial, 78 women over 18 years of age who referred to the Imam Khomeini Hospital in Sari for elective cesarean section were allocated randomly to receive either intrathecal morphine with doses of 100 μg or 200 μg, adjunct to ultra-low dose of naloxone (20 ng). Patients’ pain intensity were assessed using the VAS at 2, 4, 6 and 24 hours postoperatively. Also, the occurrence of adverse effects (pruritus, nausea, vomiting and ileus) in two groups were evaluated during the study period. Results The findings of this study indicated a significant difference in pain intensity between the two groups throughout the study period (p<0.05). Ileus was not significantly different between the two groups (P=0.48). However, using morphine at a dose of 200 μg with naloxone was associated with significantly lower rate of nausea and pruritus (P<0.001). Conclusion In the present study, patients receiving morphine at a dose of 200 μg with naloxone (20 ng) experienced significantly less pain intensity than the group receiving morphine at a dose of 100 μg with naloxone. In addition, the rate of nausea and pruritus in the group receiving morphine at a dose of 200 μg with naloxone was significantly lower than the other group.

BJMS, Vol. 24 No. 04 October’25 Page : 1131-1137

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Published

2025-11-02

How to Cite

Habibi, M. R., Ghahari, Z., Habibi, A., Baradari, A. G., & Peivandi, S. (2025). Comparison the effects of two different dose of intrathecal morphine adjunct to ultra-low dose of naloxone on pain intensity after cesarean section: A double-blind randomized clinical trial. Bangladesh Journal of Medical Science, 24(4), 1131–1137. https://doi.org/10.3329/bjms.v24i4.84684

Issue

Vol. 24 No. 4 (2025)

Section

Original Articles

License

Copyright (c) 2025 Mohammad Reza Habibi, Zohreh Ghahari, Ali Habibi, Afshin Gholipour Baradari, Saloumeh Peivandi

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