Effects of Medical Diagnostic X-rays Delivered at 0.01 or 0.05 mGy on Human Blood Cells

  • Benjamaporn Supawat Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, 50200, Thailand. Center of Radiation Research and Medical Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, Thailand, 50200
  • Jongchai Tinlapat Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, 50200, Thailand
  • Rusleena Wongmahamad Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, 50200, Thailand
  • Chuleekorn Silpmuang Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, 50200, Thailand
  • Suchart Kothan Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, 50200, Thailand. Center of Radiation Research and Medical Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, Thailand, 50200
  • Montree Tungjai Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, 50200, Thailand. Center of Radiation Research and Medical Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroroj Rd., Sripoom, Chiang Mai, Thailand, 50200
Keywords: medical diagnostic low-dose radiation, X-rays, hemolysis, mitochondrial membrane potential, lysosome, cell cycle

Abstract

Background: Low-dose X-rays are commonly used in medical imaging to help in the diagnosis ofdiseases. However, the deleterious effects of exposure to medical diagnostic low-dose X-rays remaina highly debated topic. The objective was to study the effects of medical diagnostic X-rays on humanblood cells.

Materials and Methods: We studied the effects of medical diagnostic low-dose X-rays (80kVp), i.e.,0.01 or 0.05 mGy, after the in vitro exposure of human red blood cells (RBCs) and peripheralblood mononucleated cells (PBMCs).Cells with no irradiation served as the control group. The biologicalendpoints that were used to determine the effects of medical diagnostic low-dose X-rays were hemolysisfor RBCs and mitochondrial membrane potential, lysosomes, and the cell cycle for PBMCs.

Results: Ourresults showed no changes in the hemolysis of RBCs and mitochondrial membrane potential, lysosome, orcell cycle in cells exposed to these low doses of X-rays when compared to the corresponding nonirradiatedcells at all harvest timepoints.

Conclusion: These results suggested that there were no deleterious effectsof diagnostic low-dose X-rays when human RBCs and PBMCs were exposed in vitro.

Bangladesh Journal of Medical Science Vol.20(1) 2021 p.136-144

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Abstract
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Published
2021-01-01
How to Cite
Supawat, B., Tinlapat, J., Wongmahamad, R., Silpmuang, C., Kothan, S., & Tungjai, M. (2021). Effects of Medical Diagnostic X-rays Delivered at 0.01 or 0.05 mGy on Human Blood Cells. Bangladesh Journal of Medical Science, 20(1), 136-144. https://doi.org/10.3329/bjms.v20i1.50358
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Original Articles