Features of folate cycle disorders in children with ASD

Authors

  • DmitryV Maltsev O’Bogomolets National Medical University, Kyiv, 01601,Taras Shevchenko Blv. 13, Ukraine

DOI:

https://doi.org/10.3329/bjms.v19i4.46634

Keywords:

folate cycle, autism spectrum, vitamin B12, cytomegalovirus infection

Abstract

Aim: to show the effect of genetically determined folate cycle deficiency in children with autism spectrum disorders (ASD).

Participants: 89 children (57 boys; 32 girls, Ukraine, 2-10 years old); participants were diagnosed with ASD. The control group consisted of 34 children with ASD.

Diagnostic methods:polymerase chain reaction (PCR), complex immunological research, diagnosis of infection, determination of biomarkers.

Results and discussion:Hyperhomocysteinemia was revealed in 87% of cases (p <0.05; Z <Z0.05).The indicated form of immunodeficiency was noted among 91% participants in the study, while only in 27% children of the control group had a similar immunological phenotype.The serum concentration of folic acid was increased in 64%, and reduced in 21% of cases. An increase of vitamin B12 also occurred in 64%, and vitamin B6 - only in 43% of cases.

Bangladesh Journal of Medical Science Vol.19(4) 2020 p.737-742

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Published

2020-04-12

How to Cite

Maltsev, D. (2020). Features of folate cycle disorders in children with ASD. Bangladesh Journal of Medical Science, 19(4), 737–742. https://doi.org/10.3329/bjms.v19i4.46634

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Section

Original Articles