Mutagenic properties of modified hydrothermal nanotitania extract

Authors

  • Ahmad Mukifza Harun Engineering Faculty, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah
  • Noor Baizura Ab Ghani School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
  • Nor Farid Mohd Noor School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
  • Razif Abas Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  • Mohammad Khursheed Alam Orthodontic Unit, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia

DOI:

https://doi.org/10.3329/bjms.v19i1.43890

Keywords:

Mutagenicity; Ames test; genotoxicity

Abstract

Backgrounds: The mutagenic properties of modified hydrothermal nanotitania extract were carried out using the Ames test (genotoxicity).

Materials and methods: The Ames test was performed on Salmonella strains (TA98, TA100, TA1535, TA1537 and TA 102) which contain mutations in several genes with and without S9 metabolic activation from rat liver using the standard assay. The materials were extracted in distilled water and the serial dilutions of concentration ranging from 313 to 5000 μg/mLwere used after the incubation period of 24 h at 37° C.

Results: These results suggested that all tested concentrations of the material extracts did not produce mutagenic effect in all the strains tested.

Conclusions: Findings from this study showed that the modified hydrothermal nanotitania extract was non-mutagenic under present conditions.

Bangladesh Journal of Medical Science Vol.19(1) 2020 p.159-162

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Published

2019-11-03

How to Cite

Harun, A. M., Ghani, N. B. A., Mohd Noor, N. F., Abas, R., & Alam, M. K. (2019). Mutagenic properties of modified hydrothermal nanotitania extract. Bangladesh Journal of Medical Science, 19(1), 159–162. https://doi.org/10.3329/bjms.v19i1.43890

Issue

Vol. 19 No. 1 (2020)

Section

Original Articles

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