Hepatoprotective activity of aqueous methanolic extract of Viola odorata against paracetamol-induced liver injury in mice

Authors

  • M. Imran Qadir College of Pharmacy, GC University, Faisalabad
  • Muhammad Ali College of Pharmacy, GC University, Faisalabad
  • Muhammad Ali Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan
  • Mohammad Saleem College of Pharmacy, GC University, Faisalabad
  • Muhammad Hanif Faculty of Pharmacy, Bahauddin Zakariya University, Multan

DOI:

https://doi.org/10.3329/bjp.v9i2.18049

Keywords:

Hepatoprotective, Jaundice, Silymarin, Viola odorata

Abstract

Traditionally Viola odorata is used for liver protection. To provide scientific support to its traditional use, aqueous methanolic extract of V. odorata (250 mg/kg and 500 mg/kg) was given to mice intoxicated with paracetamol. Obtained results demonstrated that the extract significantly (p<0.01-0.001) reduced paracetamol induced increase levels of serum hepatic enzymes and total bilirubin. Histopathological studies showed that the plant attenuated the hepatocellular necrosis and inflammation. HPLC results showed the presence of hepatoprotective flavonoids (isorhamnetin and luteolin) in the extract. It was concluded from the present study that V. odorata has hepatoprotective activity against paracetamol-induced liver injury in mice.

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Author Biography

M. Imran Qadir, College of Pharmacy, GC University, Faisalabad

Assistant Professor

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Published

2014-04-25

How to Cite

Qadir, M. I., M. Ali, M. Ali, M. Saleem, and M. Hanif. “Hepatoprotective Activity of Aqueous Methanolic Extract of Viola Odorata Against Paracetamol-Induced Liver Injury in Mice”. Bangladesh Journal of Pharmacology, vol. 9, no. 2, Apr. 2014, pp. 198-02, doi:10.3329/bjp.v9i2.18049.

Issue

Section

Research Articles