Methyl-α-D-glucopyranoside from Tulbaghia violacea extract induces apoptosis in vitro in cancer cells

  • Sylvester Leonard Lyantagaye Department of Molecular Biology and Biotechnology, University of Dar es Salaam
Keywords: Apoptosis, activity-guided fractionation, anti-cancer, methyl-a-D-glucopyranoside, Tulbaghia violacea

Abstract

Pro-apoptotic activity of Tulbghia violacea extracts was evaluated in order to understand the mechanisms of action that might be related to its traditional use as anticancer medicine. Apoptosis-guided purification was used to isolate active compound whose chemical structure was solved by using spectros-copic, microanalysis and X-ray crystallography techniques. T. violacea extract kills Chinese hamster ovary cells, MCF7, and HeLa cells through the induction of apoptosis Methyl-a-D-glucopyranoside was identified as one of the main pro-apoptotic compounds present in T. violacea extract. This is the first time ever demonstration that T. violacea contains methyl-a-D-glucopyranoside, which selectively kills cancer cells through apoptosis mechanisms.

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Author Biography

Sylvester Leonard Lyantagaye, Department of Molecular Biology and Biotechnology, University of Dar es Salaam
Senior Lecturer

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Published
2013-02-21
How to Cite
Lyantagaye, S. “Methyl-α-D-Glucopyranoside from Tulbaghia Violacea Extract Induces Apoptosis in Vitro in Cancer Cells”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, Feb. 2013, pp. 93-01, doi:10.3329/bjp.v8i2.13717.
Section
Research Articles