Patterns of Alpha Blocker Prescription in Benign Prostatic Hyperplasia in Bangladesh: A Paper-Based Survey
Keywords:
Benign prostatic hyperplasia, Lower urinary tract symptoms(LUTS), α-blocker, Tamsulosin, persistence rate, return rate, bladder outlet obstructionAbstract
Background: Benign prostatic hyperplasia (BPH) is the progressive enlargement of prostate gland which is an age-related process with a prevalence of about 50.0% of men age between 51 to 60, and the number jumps to 70.0% among men 60 to 69 and around 80.0% of men over 70 years of age. The treatment of BPH depends on the severity of symptoms which aims to improve symptoms, lower the risk of progression and improve quality of life.
Objective: The aim of this survey was to understand the prescription pattern of alpha blockers in the treatment of BPH among clinicians (urologist) of Bangladesh.
Methodology: This cross-sectional questionnaire-based survey was conducted between December 2022 to November 2023 in the Department of Pharmacology & Therapeutics at US-Bangla Medical College, Narayangonj, Dhaka, Bangladesh. Data regarding the management of BPH using α-blockers were filled by participants and collated for data analysis using appropriate statistical test.
Results: Total of 105 urologists’ responses were collected and the result was analyzed. According to the survey, 92.9.68% of urologists felt that severity of the BPH symptoms is most common deciding factor for medical management of BPH. For the pharmacological management of BPH patients, around 84.4% opted for α blockers monotherapy as a preferred option. Among α blockers, they preferred tamsulosin as first line therapy for management of BPH patients. In this survey, 82.1% believed that tamsulosin offers highest persistence rate among commonly prescribed α blockers. Looking at the switching to a second α-blocker, 70.4% of urologists felt that tamsulosin shows the highest return rate following initiation of a second α-blocker. More than 70% of participant felt that favorable efficacy or tolerability of tamsulosin is due to its highest persistence and highest return rates. Despite of high tolerability the most frequently complained adverse effect of tamsulosin is retrograde ejaculation in 56% cases.
Conclusions: Tamsulosin is the most commonly preferred and prescribed α-blocker by Bangladesh clinicians due to its favorable efficacy or tolerability
Journal of Current and Advance Medical Research, January 2025;12(1):16-21
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Copyright (c) 2025 Shamsun Nahar, Ferdous Mahmud Faisal, Kazi Sabiha, Sania Hoque, Farzana Yasmin, Nazmul Hossain Jony
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