Role of Serum B-type Natriuretic Peptide before and after 2hours of Spontaneous Breathing Trial among Patients under Mechanical Ventilation

Authors

  • AKM Faizul Hoque Associate Professor, Department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh
  • Manas Kanti Mazumder Medical Officer, Department of Anaesthesia, Analgesia And Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh
  • Omma Hafsa Any Associate Professor, Department of Pharmacology & Therapeutics, Army Medical College, Jashore, Bangladesh
  • Sharna Moin Assistant Professor, Department of Anatomy, Army Medical College, Jashore, Bangladesh
  • Rocky Das Gupta Medical Officer, 250 bedded General Hospital, Chittagong, Bangladesh
  • Shahadat Hossain Polash Resident (CCM), Department of Anaesthesia Analgesia & Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh
  • Rajan Mondol Resident (CCM), Department of Critical Care Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka, Bangladesh
  • Sheikh Ul Alam Resident (CCM), Department of Critical Care Medicine, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jcamr.v8i2.57438

Keywords:

Plasma BNP; anesthesia; analgesia; intensive care

Abstract

Background: Weaning of a patient from mechanical ventilation is very important for the outcomes of the patients.

Objective: The purpose of the study was to evaluate the serum level of BNP before and after 2hours of spontaneous breathing trial (SBT) among patients under mechanical ventilation.

Methodology: This prospective cohort study was conducted in the Department of Anesthesia, Analgesia and Intensive Care Medicine at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh over a period of 2 years. Study population was selected for weaning from mechanical ventilation support for the first time in the age group of more than 18 years with both sexes. Plasma BNP level of all patients was measured before and after 2 hours of spontaneous breathing trial.

Results: A total number of 30 patients were recruited for this study. One-third (33.3%) of the patients failed on SBT. The mean percent changes of BNP (pg/ml) during 2-h of SBT in weaning success and failure groups were 38.41±9.379 and 59.51±2.940 respectively (p=0.01). The receiver-operating characteristic curve analysis for BNP as a predictor of weaning outcome, showed that the area under the curve (AUC) was 0.89.

Conclusion: In conclusion BNP is currently a good predictor of different cardiac diseases.

Journal of Current and Advance Medical Research, July 2021;8(2):125-129

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Published

2021-07-01

How to Cite

Hoque, A. F. ., Mazumder, M. K. ., Any, O. H. ., Moin, S. ., Gupta, R. D. ., Polash, S. H. ., Mondol, R., & Alam, S. U. (2021). Role of Serum B-type Natriuretic Peptide before and after 2hours of Spontaneous Breathing Trial among Patients under Mechanical Ventilation. Journal of Current and Advance Medical Research, 8(2), 125–129. https://doi.org/10.3329/jcamr.v8i2.57438

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Original Articles