Evaluation of one-shot vincristine sulfate combined with surgical excision as a new regimen for treatment of canine transmissible venereal tumor

Authors

  • Khaled Abouelnasr Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. https://orcid.org/0000-0002-4507-368X
  • Mohamed A Hamed Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt. https://orcid.org/0000-0001-8822-5965
  • Rasha Eltaysh Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. https://orcid.org/0000-0003-0524-7697
  • Eman Abo Elfadl Department of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. https://orcid.org/0000-0001-9184-2761
  • Shefaa Bazeed Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Badr University, Badr, Egypt. https://orcid.org/0000-0002-0450-1449
  • Samah Ibrahim 6 Department of Clinical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. https://orcid.org/0000-0002-9430-1570
  • Liana Fericean Department of Biology and Plant Protection, Faculty of Agriculture. University of Life Sciences, Timișoara, Romania. https://orcid.org/0000-0002-0958-0342
  • Foad Farrag Department of Biology and Plant Protection, Faculty of Agriculture, University of Life Sciences, Timișoara, Romania; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt. https://orcid.org/0000-0002-4048-6717
  • Mohamed Salem Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt; Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan. https://orcid.org/0000-0002-3708-1700
  • Awad Rizk Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. https://orcid.org/0000-0002-0785-1911

Keywords:

Transmissible venereal tumors; surgical excision; dogs; vincristinesulphate

Abstract

Objective: The purpose of this study was to investigate the effectiveness of surgical excision combined with a single shot of vincristine sulfate for treating transmissible venereal tumor (TVT) in dogs. Materials and Methods: Fifty-two dogs were divided randomly into two groups (n = 26). Dogs in Group I were treated surgically by debulking the tumorous mass, whereas dogs in Group II were subjected to a combination of surgery and a single injection of vincristine sulfate. Results: Female dogs showed a high prevalence of TVT compared to males (67.3%, n = 35 vs. 32.7%, n = 17), respectively. The German shepherd’s breed showed a high prevalence of TVT compared to other breeds. There was a positive association between sex and outcomes. Most occurrences of regret in Group II were reported in females (n = 16, 61.5%) compared to male dogs (n = 10, 38.5%). There was also a positive association between breed and outcome. Most occurrences of regret in Group II were reported in German shepherd dogs (n = 16) compared to Group I (n = 7). In Group I, 15 dogs (57.7%) showed a complete regression, and 11 (42.3%) underwent recurrence. However, in Group II, 21 dogs (80.7%) showed a complete regression, and 5 dogs (19.2 %) underwent recurrence. Conclusions: It appears therefore that the simultaneous use of surgery and administration of a single dose of vincristine sulfate could be considered a combination therapy for TVT as it reduces the risk of recurrence and has a reasonable cost. Recognizing potential risk factors associated with TVT in dogs may be helpful in constructing the best preventive measures.

J. Adv. Vet. Anim. Res., 11(3): 553–559, September 2024

http://doi.org/10.5455/javar.2024.k805

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Published

2024-08-24

How to Cite

Abouelnasr, K., Hamed, M. A., Eltaysh, R., Elfadl, E. A., Bazeed, S., Ibrahim, S., … Rizk, A. (2024). Evaluation of one-shot vincristine sulfate combined with surgical excision as a new regimen for treatment of canine transmissible venereal tumor. Journal of Advanced Veterinary and Animal Research, 11(3), 553–559. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/80862

Issue

Vol. 11 No. 3 (2024)

Section

Original Articles

License

Copyright (c) 2024 Khaled Abouelnasr, Mohamed A Hamed, Rasha Eltaysh, Eman Abo Elfadl, Shefaa Bazeed, Samah Ibrahim, Liana Fericean, Foad Farrag, Mohamed Salem, Awad Rizk

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