Protective effect of avenanthramides against cisplatin induced nephrotoxicity in rats

  • Yasmin O El Amir Department of Medical Laboratory Technology, College of Applied Medical Science, Jazan University, Jazan 45142, Saudi Arabia
  • Wisam Omar Department of Medical Laboratory Technology, College of Applied Medical Science, Jazan University, Jazan 45142, Saudi Arabia
  • Amani Y Khabrani
  • Amani E Jahfali Department of Medical Laboratory Technology, College of Applied Medical Science, Jazan University, Jazan 45142, Saudi Arabia
  • Shahd M Alhakami Department of Medical Laboratory Technology, College of Applied Medical Science, Jazan University, Jazan 45142, Saudi Arabia
  • Nada M Dobab Department of Medical Laboratory Technology, College of Applied Medical Science, Jazan University, Jazan 45142, Saudi Arabia
Keywords: Avenanthramides; cisplatin; histopathology; nephrotoxicity; rats; TNF-α

Abstract

Objective: The aim of this study is to inspect the ameliorative effect of avenanthramides (AVA) on CP nephrotoxicity in Sprague-Dawley rats.

Materials and Methods: Blood samples were collected for the determination of hematological parameters. Creatinine, blood urea nitrogen (BUN), and tumor necrosis factor-α (TNF-α) were measured in serum. Specimens from both kidneys were taken for histopathological examinations.

Results: Administration of AVA resulted in significant decrease in the level of creatinine and TNF-α when compared with CP group. Histopathologically, CP-induced vacuolar degeneration and necro­sis of the kidney tubules. Administration of AVA ameliorates the histopathological alterations induced by CP.

Conclusion: AVA can be considered as a protective agent for kidneys during administration of CP. The protective effect of AVA may be related to the reduction of TNF-α which implicated in the pathogenesis of CP nephrotoxicity.

J. Adv. Vet. Anim. Res., 6(4): 521-527, December 2019

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Abstract
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Published
2019-11-19
How to Cite
Amir, Y., Omar, W., Khabrani, A., Jahfali, A., Alhakami, S., & Dobab, N. (2019). Protective effect of avenanthramides against cisplatin induced nephrotoxicity in rats. Journal of Advanced Veterinary and Animal Research, 6(4), 521-527. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/44142
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Original Articles