Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs

  • Seula Lim Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea
  • Ye In Oh Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea
  • Jong Woo Jeong Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea
  • Kun Ho Song Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea
  • Tae Sung Koo Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea
  • Kyoung Won Seo Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea
Keywords: Ascorbic acid; dog; pharmacokinetics.

Abstract

Objective: We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs.

Materials and Methods: The dogs were administered IV AA at two doses of 1.5 and 3 gm/kg for 4 h, and the AA concentration in plasma and urine pH was measured before and after administration.

Results: The plasma concentrations of AA in both groups peaked 3 h after administration. Among the two groups, the urine pH was not significantly different (p = 0.1299–0.7944). High-dose IV AA did not induce serious adverse events in dogs.  

Conclusion: The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs.

J. Adv. Vet. Anim. Res., 6(4): 481-485, December 2019

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Abstract
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Published
2019-11-18
How to Cite
Lim, S., Oh, Y., Jeong, J., Song, K., Koo, T., & Seo, K. (2019). Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs. Journal of Advanced Veterinary and Animal Research, 6(4), 481-485. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/44123
Section
Short Communications