Assessment of immune response in cattle against experimentally prepared trivalent (O, A, and Asia-1) FMD vaccine in Bangladesh
This research work was conducted to investigate the
effects of age, sex and breed on the induction of
immune response against experimentally prepared
inactivated trivalent (type O, A, and Asia-1) FMD
vaccine. Twenty six cattle were divided into four test
groups (Group A, B, C, and D; 5 cattle in each group)
and one control group (n=6) based on breed (local and
cross), age (?12 months and >12 months), and sex
(male and female). Test cattle were vaccinated with
the experimentally prepared trivalent FMD vaccine.
Pre- and post vaccinated sera from the vaccinated
cattle were collected upto 63 days, and the sera were
tested using liquid phase blocking enzyme linked
immunosorbent assay (LPBE) that was specific for
FMD serotypes O, A, and Asia-1. Antibody titers of
all the pre-vaccinated serum samples were found to
be under protection level. The females were found to
be more protected (90%; n=9/10) as compared to males
(70%; n=7/10). The titers obtained were statistically
analyzed using ttest to observe the effects of age,
breed and sex. It was observed that the mean values
of antibody titer in cattle aging >12 months against O,
A, and Asia-1 serotypes were significant (P<0.05) at
21, 49 and 63 days as compared to the values obtained
from the cattle aging ?12 months. In conclusion, the
local female cattle aging >12 months showed better
immune response towards trivalent FMD vaccine.
Copyright (c) 2015 Md. Mashfiqur Rahman Chowdhury, Md. Liakot Hossen, Khaled Bin Amin, K. H. M. Nazmul Hussain Nazir, Sultan Ahmed, Marzia Rahman, Mohammad Ferdousur Rahman Khan, Md. Tanvir Rahman, Md. Bahanur Rahman
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