Stem cell therapy in animal models of central nervous system (CNS) diseases: therapeutic role, challenges and perspectives

Authors

  • Swapan Kumar Maiti Division of Surgery, Indian Veterinary Research Institute, Izatnagar?243122, Uttar Pradesh
  • A.R. Ninu Division of Surgery, Indian Veterinary Research Institute, Izatnagar?243122, Uttar Pradesh
  • V. Remya Division of Surgery, Indian Veterinary Research Institute, Izatnagar?243122, Uttar Pradesh
  • T.B. Sivanarayanan Division of Surgery, Indian Veterinary Research Institute, Izatnagar?243122, Uttar Pradesh
  • Susan Cherian Division of Pathology, Indian Veterinary Research Institute, Izatnagar?243122, Uttar Pradesh
  • Deepak Kumar Department of Veterinary Public Health, College of Veterinary Sciences & Animal Husbandry, R.K. Nagar? 799008, Tripura
  • Mr. Amarpal Division of Surgery, Indian Veterinary Research Institute, Izatnagar?243122, Uttar Pradesh

Keywords:

Animal models, Cell replacement, Challenges, CNS diseases, Scaffold, Stem cell therapy

Abstract

Many human diseases relating to central nervous system (CNS) are mimicked in animal models to evaluate the efficacy of stem cell therapy. The therapeutic role of stem cells in animal models of CNS diseases include replacement of diseased or degenerated neuron, oligodendrocytes or astrocytes with healthy ones, secretion of neurotrophic factors and delivery of therapeutics/genes. Scaffolds can be utilized for delivering stem cells in brain. Sustained delivery of stem cells, lineage specific differentiation, and enhanced neuronal network integration are the hallmarks of scaffold mediated stem cell delivery in CNS diseases. This review discusses the therapeutic role, challenges and future perspectives of stem cell therapy in animal models of CNS diseases.

DOI: http://dx.doi.org/10.5455/javar.2014.a17

J. Adv. Vet. Anim. Res., 1(3): 75-85, September 2014

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Published

2014-07-19

How to Cite

Maiti, S. K., Ninu, A., Remya, V., Sivanarayanan, T., Cherian, S., Kumar, D., & Amarpal, M. (2014). Stem cell therapy in animal models of central nervous system (CNS) diseases: therapeutic role, challenges and perspectives. Journal of Advanced Veterinary and Animal Research, 1(3), 75–85. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/19611

Issue

Section

Review Articles