Drug resistance pattern of M. tuberculosis in category II treatment failure pulmonary tuberculosis patients

Authors

  • Fahmida Rahman Department of Microbiology, Ibrahim Medical College
  • Sadia Sharmin Department of Microbiology, Anwer Khan Modern Medical College
  • Md Mustafa Kamal NTRL, NIDCH
  • Md Ruhul Amin Miah Department of Microbiology & Immunology, BSMMU

DOI:

https://doi.org/10.3329/imcj.v7i1.17741

Keywords:

MDR-TB, XDR-TB, Category II treatment failure tuberculosis

Abstract

This study was designed to determine the extent of drug resistance of M. tuberculosis (MTB) isolated from category II treatment failure pulmonary tuberculosis (PTB) patients. A total of 100 Ziehl-Neelsen (Z-N) smear positive category II failure PTB patients were included in this study. Sputum culture was done in Lowenstein-Jensen (L-J) media. Conventional proportion method on Lowenstein-Jensen (L-J) media was used to determine the drug susceptibility of M. tuberculosis to isoniazid (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA). Out of 100 sputum  samples, a total of 87 samples were positive by culture. Drug susceptibility test (DST) revealed that 82 (94.25%) isolates were resistant to one or more anti -TB drugs. Resistance to isoniazide (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA) was 94.25%, 82.75%, 29.90% and 3.45% respectively. Among these isolates, 79.31% and 3.45% isolates were multi-drug resistant (MDR) and extended drug resistant (XDR) M. tuberculosis respectively. High rate of anti-tubercular drug resistance was observed among the category II treatment failure TB patients.

DOI: http://dx.doi.org/10.3329/imcj.v7i1.17741

Ibrahim Med. Coll. J. 2013; 7(1): 9-11

Downloads

Download data is not yet available.
Abstract
870
PDF
615

Downloads

Published

2014-01-20

How to Cite

Rahman, F., Sharmin, S., Kamal, M. M., & Miah, M. R. A. (2014). Drug resistance pattern of M. tuberculosis in category II treatment failure pulmonary tuberculosis patients. Ibrahim Medical College Journal, 7(1), 9–11. https://doi.org/10.3329/imcj.v7i1.17741

Issue

Section

Original Articles