Serum Total IgE in Assessing Disease Severity among Patients with Chronic Spontaneous Urticaria

Abstract

Immunoglobulin E (IgE) and its high-affinity receptor, FcεRI, play key roles in the pathogenesis of chronic spontaneous urticaria (CSU). Emerging evidence suggests that total serum IgE may serve as a useful biomarker for assessing disease activity, identifying disease endotypes, and predicting treatment responses in patients with CSU. A cross-sectional study was carried out in the Department of Dermatology & Venereology of Bangladesh Medical University (BMU), Dhaka, Bangladesh, between January and December of 2025, to evaluate the role of serum total IgE levels in assessing disease severity among patients with chronic spontaneous urticaria (CSU). A total of 83 patients with CSU were included in the study. Total serum IgE levels and disease severity were assessed. The majority (48.2%) of the patients belonged to age 21-30 years with female patients were predominant 46 (55.4%) The median total serum IgE levels was 92.0 (65.0-215.0) IU/mL. The prevalence of elevated IgE levels (>100 IU/mL) was 45.8% among patients. The median disease duration differed significantly in mild (6.5 months), moderate (12.0 months) and severe disease (32.0 months) (p<0.001). There was a significant positive correlation between chronic urticaria severity score vs disease duration (r=0.775; p=0.001), while total serum IgE vs. disease duration (r=0.695; p=0.001) and chronic urticaria severity score vs total serum IgE (r=0.688; p=0.001). The elevated total serum IgE levels were significantly associated with a higher disease severity and duration.

 CBMJ 2026 July: Vol. 15 No. 02 P:396-403