Application of plackett-burman design to benzylation of o-cresol with benzyl alcohol

  • M Shahruzzaman Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • D Saha Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • MS Rahman Institute of Leather Engineering and Technology, University of Dhaka, 44-50 Hazaribagh, Dhaka-1209
  • MS Rahman Institute of Leather Engineering and Technology, University of Dhaka, 44-50 Hazaribagh, Dhaka-1209
Keywords: Plackett-burman, o-cresol, Benzyl alcohol, Catalyst (Aluminium chloride), Variables, Polynomial model

Abstract

Plackett-Burman design was employed to study the reaction of o-cresol with benzyl alcohol in the presence of anhydrous aluminium chloride as catalyst for screening variables. The variables chosen for the investigation were temperature, molar ratio of o-cresol to benzyl alcohol, amount of anhydrous AlCl3 catalyst (% by wt. of o-cresol), addition time (ta h), stirring time (ts h), stirring speed (rpm). Among these variables temperature, molar ratio of o-cresol to benzyl alcohol and amount of anhydrous AlCl3 were found to be important. A set of trials was planned according to a 3 factor 2-level Yates pattern experimental design with 2 replicates and the center point trial with 4 replicates. The critical response was the yield of benzyl o-cresol. Main effects as well as two- and three- factor interaction effects were statistically significant. A polynomial model was developed and the adequacy of the suggested model was checked up.

Bangladesh J. Sci. Ind. Res. 50(3), 169-180, 2015

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Author Biography

M Shahruzzaman, Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000


Published
2015-11-05
How to Cite
Shahruzzaman, M., Saha, D., Rahman, M., & Rahman, M. (2015). Application of plackett-burman design to benzylation of o-cresol with benzyl alcohol. Bangladesh Journal of Scientific and Industrial Research, 50(3), 169-180. https://doi.org/10.3329/bjsir.v50i3.25580
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Articles