Antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats

  • Yakubu M. Toyin Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, Ilorin
  • Opakunle F. Khadijat Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, Ilorin
  • Salimon S. Saoban Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, Ilorin
  • Ajiboye T. Olakunle Antioxidants, Free Radicals and Toxicology Research Laboratory, Department of Chemical Sciences, Fountain University, Osogbo
  • Bamisaye F. Abraham Department of Biochemistry, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State
  • Quadri A. Luqman Phytomedicine, Toxicology and Reproductive Biochemistry Research Laboratory, Department of Biochemistry, Ilorin
Keywords: Antidiarrhea, Castor oil, Ceratotheca sesamoides, Enteropooling, Gastrointestinal transit, Pedaliaceae

Abstract

The antidiarrheal effects of the aqueous leaf extract of C. sesamoides at 25, 50 and 100 mg/kg body weight was evaluated in female rats using gastrointestinal transit, diarrhea and enteropooling induced by castor oil models. The extract was positive for alkaloids, saponins, flavonoids and phenolics. The 25 mg/kg body weight of the extract significantly (p<0.05) prolonged the onset time of diarrhea, decreased the fecal parameters (number, water content, fresh weight, total number of wet feaces) with no episode in the animals treated with 50 and 100 mg/kg body weight. The activity of small intestine Na+-K+ ATPase increased (p<0.05) while the nitric oxide, volume and mass of intestinal fluid as well as the distance travelled by the charcoal meal decreased. The patterns of changes were similar to the reference drugs. Overall, the antidiarrheal activity of the aqueous leaf extract of Ceratotheca sesamoides may be due to alkaloids, phenolics, flavonoids and saponins present in the extract.

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Published
2012-03-20
How to Cite
Toyin, Y., O. Khadijat, S. Saoban, A. Olakunle, B. Abraham, and Q. Luqman. “Antidiarrheal Activity of Aqueous Leaf Extract of Ceratotheca Sesamoides in Rats”. Bangladesh Journal of Pharmacology, Vol. 7, no. 1, Mar. 2012, pp. 14-20, doi:10.3329/bjp.v7i1.9789.
Section
Research Articles