Synthesis and anticonvulsant activity of Schiff’s bases of 3-{[2-({(E)-[(substituted) phenyl] methylidene} amino) ethyl] amino} quinoxalin-2(1H)-one

  • Ratnadeep V. Ghadage Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 416416
  • Pramod J. Shirote Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 416416
Keywords: Anti-covulsant, Microwave method, Phillips condensation, Quinoxaline, Schiff’s bases,


In an effort to develop potent anticonvulsant agents, we have synthesized some novel schiffs bases of 3-{[2-({(E)-[substituted) phenyl] methylidene} amino) ethyl] amino} quinoxalin-2(1H)-one and evaluated for in vivo anticonvulsant activity. All the compounds were characterized by IR, 1H NMR data. This activity was carried out on pentylenetetrazole-induced seizure model. Compounds (IIIb) and (IIIc) Showed maximum time for straub tail and clonic convulsions. That means they possess good activity compared with standard. Animals treated with compounds (IIIb) and (IIIe) were recovered from this activity.


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Author Biography

Ratnadeep V. Ghadage, Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli 416416
Reasech student


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How to Cite
Ghadage, R., and P. Shirote. “Synthesis and Anticonvulsant Activity of Schiff’s Bases of 3-{[2-({(E)-[(substituted) Phenyl] Methylidene} Amino) Ethyl] Amino} Quinoxalin-2(1H)-One”. Bangladesh Journal of Pharmacology, Vol. 6, no. 2, Nov. 2011, pp. 92-99, doi:10.3329/bjp.v6i2.8671.
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