A comparative study on the effect of streptokinase between diabetic and non-diabetic myocardial infarction patients

Authors

  • Md. Anup Rahman Chowdhury Department of Pharmacology, Sylhet M. A. G. Osmani Medical College, Sylhet 3100
  • A. K. M. Mosharrof Hossain Department of Pharmacology, Sylhet M. A. G. Osmani Medical College, Sylhet 3100
  • Sudhangshu Ranjan Dey Department of Cardiology, Sylhet M. A. G. Osmani Medical College Hospital, Sylhet 3100
  • A. K. M. Akhtaruzzaman Department of Cardiology, Sylhet M. A. G. Osmani Medical College Hospital, Sylhet 3100
  • Nur-A-Farhana Islam Department of Biochemistry, North East Medical College, Sylhet 3100

DOI:

https://doi.org/10.3329/bjp.v3i1.822

Keywords:

Diabetes mellitus, Myocardial infarction, Streptokinase

Abstract

A prospective interventional study was carried out to compare the thrombolytic effect of streptokinase between diabetic and non-diabetic myocardial infarction patients. Out of 187 study subjects with acute ST segment elevation myocardial infarction (STEMI), admitted at coronary care unit, 126 patients were non-diabetic and 61 patients were diabetic. Streptokinase was administered to all patients. Resolution (reduction) of elevated ST segment was evaluated after 90 minutes of streptokinase administration. Successful reperfusion (?70% ST-resolution) was significantly higher in non-diabetic than diabetic (p<0.001), while failed reperfusion (<30% ST resolution) was significantly higher in diabetic patients (p<0.001). It may be concluded that diabetes mellitus might affect the thrombolytic outcome of acute myocardial infarction patients with diabetes mellitus.

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Published

2008-04-20

How to Cite

Chowdhury, M. A. R., A. K. M. M. Hossain, S. R. Dey, A. K. M. Akhtaruzzaman, and N.-A.-F. Islam. “A Comparative Study on the Effect of Streptokinase Between Diabetic and Non-Diabetic Myocardial Infarction Patients”. Bangladesh Journal of Pharmacology, vol. 3, no. 1, Apr. 2008, pp. 1-7, doi:10.3329/bjp.v3i1.822.

Issue

Vol. 3 No. 1 (2008)

Section

Research Articles

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