Design synthesis and biological evaluation of 2-methylphenyl semicarbazone derivatives


  • Manmohan Singhal School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan
  • Arindam Paul GD Memorial College of Pharmacy, Jodhpur, Rajasthan
  • Hemendra Pratap Singh BN College of Pharmacy, Udaipur, Rajasthan



Antipyretic, Chalcone, Cow milk, Pyrexia, Semicarbazone


We have used pharmacophore hybridization technique of drug design and designed a pharmacophore model 2-methylphenylsemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site etc using ligandscout-2.02 software. A series of 2-methylphenyl-semicarbazone was synthesized and evaluated for their antipyretic activity using boiled cow milk induced pyrexia in rabbits. Compound 11 was the most active compound. The possible metabolites of some selected synthesized chalconesemicarbazones were predicted by computational method using Pallas version-3.1 ADME-Tox prediction software. The major pathway of metabolism was found to be p-hydroxylation and amide hydrolysis.


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How to Cite

Singhal, M., A. Paul, and H. P. Singh. “Design Synthesis and Biological Evaluation of 2-Methylphenyl Semicarbazone Derivatives”. Bangladesh Journal of Pharmacology, vol. 6, no. 1, June 2011, pp. 1-7, doi:10.3329/bjp.v6i1.7771.



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