Cytotoxicity study of pyrazole derivatives


  • Nusrat Binta Ahasan Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342



Cytotoxicity, Dibromopyrazole, Ethyl acetoacetate, Phenyl hydrazine, Pyrazole


Pyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2) . Their cytotoxicity effects were measured by brine shrimp lethality bioassay. Among them the compounds 2(b) , 2(f1) , and 2(f2) were highly active according to IC50 values 19.50, 19.50 and 20 ppm respectively. The rest of compounds 2(a) , 2(c) , 2(d1) , and 2(d2) having IC50 values 38, 33.50, 37.50, 36, 37.50 and 36 ppm in that order, were moderately active.


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How to Cite

Ahasan, N. B., and M. R. Islam. “Cytotoxicity Study of Pyrazole Derivatives”. Bangladesh Journal of Pharmacology, vol. 2, no. 2, June 2007, pp. 81-87, doi:10.3329/bjp.v2i2.575.



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