Cytotoxicity study of pyrazole derivatives
Pyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2) . Their cytotoxicity effects were measured by brine shrimp lethality bioassay. Among them the compounds 2(b) , 2(f1) , and 2(f2) were highly active according to IC50 values 19.50, 19.50 and 20 ppm respectively. The rest of compounds 2(a) , 2(c) , 2(d1) , and 2(d2) having IC50 values 38, 33.50, 37.50, 36, 37.50 and 36 ppm in that order, were moderately active.
Badawey ESAM, El-Ashmawey IM. Non-steroidal anti-inflammatory agents. Part 1: Anti-inflammatory, analgesic and antipyretic activity of some new 1-(pyrimidin-2-yl)-3-pyrazoline-5-ones and 2-(pyrimidin-2-yl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-ones. Eur J Med Chem. 1998; 33: 349-61.
El-Zohry MF, Younes MI, Metwally SA. Synthesis and some reactions of 3-methyl-2-pyrazolin-4,5-dione. Synthesis 1984; 972.
Finar IL. Stereochemistry and the chemistry of natural products. 5th ed. Singapore, Longman, 1994, pp 608-11.
Gürsoy A, Demirayak S, Çapan G, Erol K, Vural K. Synthesis and preliminary evaluation of new 5-pyrazolinone derivatives as analgesic agents. Eur J Med Chem. 2000; 35: 359-64.
Islam MR, Khayer K, Ahmad MM. Synthesis of 3-methylpyrazoline-5-one and its 3,3-dimethyl-5,5-ethene-bis-2-pyrazoline-4,4-dione, substituted cyclic tri-azothione and N-acetylated derivatives. J Bangladesh Chem Soc. 2001; 14: 33.
Islam MR, Muhsin M. Synthesis of 5-chloroisatin-6,7-dimethylisatin and their carbohydrozone and Δ2 -1,3,4-oxadiazoline and their cytotoxicity studies. Bangladesh J Pharmacol. 2007; 2: 7-12.
Islam MR. Cytoxicity studies on Δ2-1,3,4-thiadiazoline heterocycles. Proceedings Bangladesh Chem Congress 2004. 1LC5, p 157.
Kubota S, Ueda Y, Fujikane K, Toyooka K, Shibuya M. Synthesis of 4-acyl-2-(acylamino)-Δ2-1,3,4-thiadiazolines and 4-acyl-2-amino-Δ2-1,3,4-thiadiazolines by acylation of thiosemicarbazones. J Org Chem. 1980; 45: 473-77.
Shaha GC, Khayer K, Islam MR, Chowduri MS. Synthesis of thiocarbohydrazide, some thiocarbo-hydrazoenes and their cyclized products as probes for pharmalogical studies. Indian J Chem.1992; 31B: 547.
Solis PN, Wright CW, Anderson MM, Gupta, Phillipson JD. A microwell cytotoxicity assay using Artemia salina (brine shrimp). Planta Med. 1997; 59: 250-252.
Uddin MI. Synthesis and biological evaluation of some pyrazolone as anticancer agents. MSc Thesis. Jahangirnagar University, 2000.
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